冷热交替治疗仪的探针设计及应用

发布时间：2018-06-09 05:52

本文选题：探针设计 + 数值模拟　；参考：《上海交通大学》2012年硕士论文

【摘要】：肿瘤的冷热交替治疗可以克服单冷和单热疗法的不足,提高肿瘤的治愈率,同时可以保护正常的组织不受损害,已成为近年肿瘤热物理治疗研究的一个热点方向。本实验室自主研发的冷热交替治疗仪,用液氮作为冷媒制冷,射频加热。目前正在进行大量的动物实验,但原有探针在进行动物实验时存在治疗探针不能与皮下肿瘤完全有效接触,治疗效果被削弱的问题。本研究的主要目的是为冷热交替治疗系统研制新型的探针。针对动物实验中不同类型、不同尺寸的肿瘤,设计并制造新型的治疗探针,并增加测温功能。新型探针是基于数值模拟以设定探针参数。本研究通过精确建模和数值模拟,研究了内管直径、探针长度、入口压力等因素对制冷效果的影响。发现较大的内管直径和较长的探针长度以及较高的入口压力使治疗探针的制冷能力增强。同时还研究了射频对组织的作用,发现新型平面探针在加热时由于对组织作用面积大,加热均匀,不会产生组织的焦化现象。根据数值模拟优选出达到最好疗效的探针参数,并考虑实际操作对探针尺寸的限制,本文最终确定了针对不同类型和尺寸肿瘤的探针参数,并制作了相应的探针。通过对探针在胶体内温度场的直接测量,验证了模拟结果的准确性。新型探针被用于小鼠的皮下肿瘤治疗,以及兔子肝脏肿瘤治疗的研究。对移植过皮下肿瘤的小鼠进行过冷热交替治疗。通过对治疗方案的不断摸索,现在对直径小于1cm的皮下肿瘤有较高的治愈率,约为87.5%。新型探针是冷热交替治疗仪的重要组成部分,为研究冷热交替疗法治疗各种肿瘤的效果提供硬件基础。本文中对影响探针制冷效果的因素的讨论,以及探针参数的选择对今后设计医用治疗探针有重要借鉴意义。
[Abstract]:The alternative therapy of cold and heat can overcome the deficiency of single cold and single heat therapy, improve the cure rate of tumor and protect the normal tissue from damage. It has become a hot topic in the research of tumor thermophysiotherapy in recent years. Our laboratory developed an alternate cooling and heat therapy instrument, using liquid nitrogen as refrigerant and RF heating. At present, a large number of animal experiments are being carried out, but when the original probe is used in animal experiments, the therapeutic probe cannot be completely effectively contacted with the subcutaneous tumor. The main purpose of this study is to develop a new probe for alternate cold and heat therapy system. A new type of therapeutic probe is designed and manufactured for different types and sizes of tumors in animal experiments, and the function of temperature measurement is increased. The new probe is based on numerical simulation to set the probe parameters. Through accurate modeling and numerical simulation, the effects of inner tube diameter, probe length and inlet pressure on refrigeration effect were studied. It was found that the larger inner tube diameter, longer probe length and higher inlet pressure enhanced the cooling ability of the therapeutic probe. At the same time, the effect of RF on the tissue is studied. It is found that the new planar probe will not coking the tissue because of its large area and uniform heating. According to the numerical simulation, the best probe parameters were selected and the limit of the probe size was considered. Finally, the probe parameters for different tumor types and sizes were determined, and the corresponding probes were made. The accuracy of the simulation results was verified by the direct measurement of the temperature field of the probe in the colloid. The new probe was used in the treatment of subcutaneous tumor in mice and in the treatment of rabbit liver tumor. The mice transplanted with subcutaneous tumor were treated alternately between cold and heat. Through the continuous exploration of the treatment plan, there is a higher cure rate for subcutaneous tumors whose diameter is less than 1cm, which is about 87.5.The new probe is an important part of the alternately cold and hot therapeutic apparatus. To provide the hardware basis for the study of the effect of alternate cold and heat therapy on various kinds of tumors. In this paper, the factors affecting the cooling effect of the probe and the selection of the probe parameters are of great significance for the design of the medical therapeutic probe in the future.
【学位授予单位】：上海交通大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.6

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