硅在生物材料领域的应用:增加材料生物活性不影响其机械性能

发布时间：2018-06-16 17:40

本文选题：硅 + 羟基磷灰石　；参考：《中国组织工程研究》2017年02期

【摘要】：背景:硅在骨骼发育中具有重要作用,生物活性硅酸盐玻璃是当今生物活性材料研究的热点。利用硅的生物学作用,已研制出各种不同的生物材料。目的:探讨硅的生物学功能和含硅生物材料的研究进展。方法:检索相关期刊论文、Pub Med、Springer Link、Elsevier Science Direct数据库,查找关于硅的生物学作用和在生物材料领域应用的相关文献,对资料进行筛选,排除重复研究和关联性较小的文献,保留与硅在生物材料领域应用关联性较大的文献。结果与结论:共纳入68篇符合标准的英文文献。经分析得出:骨骼中的硅具有重要的化学和生物学作用。细胞外基质中的硅可在糖胺聚糖和蛋白聚糖合成过程中与它们相互作用,并在羟基磷灰石晶体的晶格结构中形成离子取代。此外,生物活性玻璃溶解产物(主要是硅酸)对体外成骨细胞分子生物学有显著影响,可调节多种基因,包括重要的成骨细胞标志物、细胞周期调控因子和细胞外基质蛋白的基因表达。硅已被证实能够增加各种材料的生物活性,且不影响他们的机械性能或诱导细胞毒性。
[Abstract]:Background: Silicon plays an important role in bone development. Bioactive silicate glass is a hotspot in the research of bioactive materials. Various biological materials have been developed using the biological function of silicon. Objective: to investigate the biological function of silicon and the research progress of silicon-containing biomaterials. Methods: to search the database of Pub MedSpringer Linker Elsevier Science Direct, search the relevant literature about the biological function of silicon and its application in the field of biomaterials, screen the data and exclude the duplicate research and the literature with little relevance. Retention of literature that is highly relevant to the application of silicon in the field of biomaterials. Results & conclusion: a total of 68 English literatures were included. It is concluded that silicon in bone has important chemical and biological functions. Silicon in extracellular matrix interacts with glycosaminoglycan and proteoglycan and forms ion substitution in the lattice structure of hydroxyapatite crystal. In addition, bioactive glass dissolving products (mainly silicic acid) have a significant effect on the molecular biology of osteoblasts in vitro and regulate many genes, including important osteoblast markers. Gene expression of cell cycle regulators and extracellular matrix proteins. Silicon has been shown to increase the biological activity of various materials without affecting their mechanical properties or inducing cytotoxicity.
【作者单位】：上海中医药大学附属普陀医院骨科;
【基金】：上海市普陀区卫生系统自主创新项目(2013PTKW015)~~
【分类号】：R318.08

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