组织工程技术在感染性骨缺损治疗中的应用及优势

发布时间：2018-06-24 19:37

本文选题：骨疾病 + 感染性　；参考：《中国组织工程研究》2017年28期

【摘要】：背景:感染性骨缺损的治疗方法很多,但没有一种同时兼备缓释抗炎、成骨活性、骨传导作用、可降解吸收的一期治疗方法。目的:探讨骨组织工程技术治疗感染性骨缺损的研究进展。方法:应用计算机检索PubMed数据库、万方数据库及CNKI中国知网数据库2000至2016年相关文献,包括:(1)抗生素局部应用相关基础、临床研究;(2)抗生素缓释系统治疗感染性骨缺损的基础研究;(3)种子细胞的来源及成骨机制相关基础研究;(4)支架材料研发相关文章。共纳入55篇文献进行分析。结果与结论:(1)局部应用抗生素的方法在治疗骨髓炎中均有着不同的效果;(2)骨组织工程学的发展为骨缺损治疗带来新的希望,选择优良的种子细胞也因此成为了研究的热点和难点;(3)抗生素、种子细胞和可吸收支架材料的完美结合为感染性骨缺损的一期治疗提供可能。
[Abstract]:Background: there are many methods for the treatment of infectious bone defect, but there is no one-stage treatment with slow-release anti-inflammatory, osteogenic activity, bone conduction and biodegradable absorption. Objective: to investigate the progress of bone tissue engineering in the treatment of infectious bone defects. Methods: the relevant literatures of PubMed database, Wanfang database and CNKI database from 2000 to 2016 were searched by computer, including: (1) the basis of local application of antibiotics; Clinical studies; (2) basic research of antibiotic sustained-release system for the treatment of infectious bone defects; (3) basic research on the origin of seed cells and osteogenesis mechanism; (4) related articles on research and development of scaffold materials. A total of 55 articles were analyzed. Results and conclusion: (1) the local application of antibiotics has different effects in the treatment of osteomyelitis, (2) the development of bone tissue engineering brings new hope for the treatment of bone defect. Therefore, the selection of excellent seed cells has become a hot and difficult point. (3) the perfect combination of antibiotics, seed cells and absorbable scaffold materials provides the possibility for the primary treatment of infectious bone defects.
【作者单位】：内蒙古医科大学研究生学院;内蒙古医科大学第二附属医院创伤骨科;内蒙古医科大学第二附属医院小儿骨科;内蒙古医科大学第二附属医院骨病骨肿瘤科;
【基金】：内蒙古自治区自然科学基金项目(2015MS0830)~~
【分类号】：R318.08;R68

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