低频超声促进哺乳期大鼠泌乳的实验研究

发布时间：2018-06-25 14:32

本文选题：低频超声 + 大鼠　；参考：《南方医科大学学报》2012年05期

【摘要】：目的探讨低频超声用于促进哺乳期泌乳的可行性。方法 24只SD哺乳大鼠,每只母鼠1窝带仔10只。随机分为3组,每组8窝,分别为对照组(假辐照)、5 min组(超声辐照5 min/乳腺.d)和10 min组(超声辐照10 min/乳腺.d)。从分娩第2天起,使用低频超声(频率40 kHz,强度0.26 w/cm2)对母鼠乳腺予以辐照,连续7 d。检测母鼠泌乳量、仔鼠体增重、乳腺器官指数、血清催乳素(PRL)以及乳腺组织学检查。结果 10 min组泌乳量、仔鼠体增重、乳腺器官指数及PRL浓度均显著大于对照组和5 min组(P0.05);光镜下10 min组乳腺腺泡明显增多,腺腔扩张,5 min组无明显变化。结论一定剂量低频超声辐照能够促进PRL分泌和乳腺发育,提高大鼠的泌乳性能,有望成为一种促进哺乳期乳汁分泌的理疗新方法。
[Abstract]:Objective to explore the feasibility of using low frequency ultrasound to promote lactation during lactation. Methods 24 SD rats were breast-fed, 10 rats were born in one litter of each female rat. They were randomly divided into 3 groups: control group (sham irradiation) 5 min group (5 min/ mammary gland per day) and 10 min group (10 min/ mammary gland. D). From the second day of delivery, low frequency ultrasound (frequency 40 kHz, intensity 0. 26 w/cm2) was used to irradiate the mammary gland of female mice for 7 days. The lactating quantity, body weight gain, mammary organ index, serum prolactin (PRL) and breast histology were measured. Results the lactation volume, body weight gain, mammary organ index and the concentration of mammary gland in 10 min group were significantly higher than those in control group and 5 min group (P0.05), but the acinar acinus of 10 min group was significantly increased under light microscope, but there was no significant change in 5 min group of dilatation of glandular cavity. Conclusion low frequency ultrasound irradiation at a certain dose can promote PRL secretion and breast development and improve the lactation performance of rats. It is expected to be a new physiotherapy method for promoting lactation milk secretion.
【作者单位】：重庆医科大学生物医学工程学院//省部共建超声医学工程国家重点实验室//超声医学工程重庆市市级重点实验室;
【基金】：国家自然科学基金(31000435) 国家重点基础研究发展计划(973计划)(2011CB707902) 国家重大仪器专项(81127901)~~
【分类号】：R714.6

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