便携式经颅直流电刺激系统设计与实现

发布时间：2018-06-27 22:47

本文选题：便携 + 直流电刺激　；参考：《电子科技大学》2017年硕士论文

【摘要】：神经系统类疾病是世界上发病率、致残率、死亡率非常高的疾病。如何更有效地治疗神经系统疾病,减少患者的痛苦及提高患者的生活质量已成为神经科学领域研究的热门话题。目前许多研究表明,经颅直流电刺激对神经系统类疾病的临床治疗具有积极的效果。国外得到最广泛应用的是德国NeuroConn公司和美国Soterix公司的经颅直流电刺激产品,但是国内还没有专业的经颅直流电刺激产品。NeuroConn公司和Soterix公司已合作研发一套便携式经颅电刺激产品,但是刺激参数必须连接电脑才可调并且没有充电接口,因此本论文自主研究并设计了一套低功耗、可充电、刺激参数数字可调、多种刺激模式、安全可靠的便携式经颅直流电刺激系统。本文研制出的经颅直流电刺激系统主要由硬件电路和人机交互界面组成。硬件电路设计包括设计具有数字可调的电流源电路、实时监控的过流保护电路和高精度的阻抗检测电路。电流源电路是整个经颅直流电刺激系统的基础,电流输出在0~1mA范围内时误差小于20μA,电流输出在1mA~2mA范围内时误差小于50μA,数字最小可调步长为50μA。过流保护电路能够实时监控刺激电流幅度,来保证刺激电流在人体安全阈值内。阻抗检测电路的功能是检测电极与头皮的接触状态,系统的阻抗检测在3.92kΩ以下,其误差低至70Ω。另外,经颅直流电刺激系统具有自动增减功能,当电流幅度设置前后变化时,系统会根据之前电流幅度逐渐增减到之后的设定值。因此,用户不会因为刺激期间电流幅度剧烈变化,而感到刺痛感。另外,系统样机的最大功耗约为600mW,可以连续工作12个小时。本文经过系统方案设计、各模块电路设计、PCB制板、系统软硬件调试后对样机各项参数进行测试,符合人体电气安全标准。另外,本文利用研制的样机进行了经颅直流电刺激健康人体实验,分析了经颅直流电刺激样机的刺激效果,验证了经颅直流电刺激样机的有效性和可靠性。本论文设计的便携式经颅直流电刺激样机可以为神经系统疾病的临床实验与治疗提供一个较好的电刺激系统平台。
[Abstract]:Neurological diseases are very high morbidity, disability and mortality in the world. How to treat nervous system diseases more effectively, reduce the suffering of patients and improve the quality of life of patients has become a hot topic in the field of neuroscience. At present, many studies have shown that transcranial direct current stimulation has a positive effect on the clinical treatment of nervous system diseases. The most widely used products abroad are transcranial direct current stimulation products from NeuroConn of Germany and Soterix of the United States. However, there is no professional transcranial direct current stimulation product in China. NeuroConn and Soterix have developed a portable transcranial direct current stimulation product. However, the stimulation parameters must be connected to the computer to adjust and have no charging interface. Therefore, this paper has independently studied and designed a set of low power consumption, rechargeable, digital adjustable stimulus parameters and various stimulation modes. Safe and reliable portable transcranial direct current stimulation system. The transcranial direct current stimulation system is mainly composed of hardware circuit and man-machine interface. The hardware circuit design includes the design of a digital adjustable current source circuit, a real-time monitoring overcurrent protection circuit and a high precision impedance detection circuit. The current source circuit is the basis of the whole transcranial direct current stimulation system. The current output error is less than 20 渭 A in the 0~1mA range, the current output error is less than 50 渭 A in the 1mA~2mA range, and the minimum adjustable step size is 50 渭 A. Over-current protection circuit can monitor the amplitude of stimulus current in real time to ensure that the stimulation current is within the human safety threshold. The function of the impedance detection circuit is to detect the contact state between the electrode and the scalp. The impedance detection of the system is below 3.92 k 惟, and the error is as low as 70 惟. In addition, the transcranial direct current stimulation system has the function of automatic increase and decrease. When the current amplitude changes before and after the current amplitude is set, the system will gradually increase and decrease to the following set value according to the previous current amplitude. Therefore, users will not feel tingling because of the sharp changes in the magnitude of the current during the stimulation. In addition, the maximum power consumption of the system prototype is about 600 MW, which can work for 12 hours. After the design of the system scheme and the circuit design of each module, the PCB board is designed. After debugging the hardware and software of the system, the parameters of the prototype are tested, which conforms to the human body electrical safety standard. In addition, the experimental results of transcranial direct current (TDC) stimulation in healthy volunteers were carried out by using the prototype, and the effectiveness and reliability of the TDCS prototype were analyzed, and the validity and reliability of the TDC prototype were verified. The portable transcranial direct current electrical stimulation prototype designed in this paper can provide a good platform for the clinical experiment and treatment of nervous system diseases.
【学位授予单位】：电子科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R741;TH789

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