抗感染尿管获中国专利现况

发布时间：2018-06-30 09:13

本文选题：泌尿道感染 + 生物相容性材料　；参考：《中国组织工程研究》2015年25期

【摘要】：背景:导管相关尿路感染为临床诊治难点,其致病关键在于材料表面细菌生物膜形成,通过构建具有抗感染功能尿管成为研发热点。目的:回顾抗感染尿管获中国专利的现况。方法:以Google专利(http://www.google.com/advanced_patent_search)为检索平台,以"返回具有以下专利名的专利:尿管"进行检索,检索截至2014-03-26。结果与结论:初检共获得949条结果,剔除无关专利,仅纳入明确陈述抗感染或抗菌尿管专利,共计23条中国专利结果纳入分析。结果表明:1抗菌涂层药物选择:大多数专利为纳米无机金属离子抗菌剂,仅4项含有抗生素涂层。2药物涂层数:大部分为多层/复合涂层。3药物释放方式:大多专利陈述为缓释释放,但释放可控性未予以交代。4制备工艺:1项专利采用化学键或离子键结合方式,2项采取共混方式,1项采取镀复,1项采用高压静电纺丝技术,12项(52.17%)陈述采用物理浸渍方式。5抗菌方式:1项为超声抗菌、1项为无菌套筒、1项为亲水涂层、1项为抗感染剂与高分子材料共混制备导管,其余20项(82.61%)均为含抗菌剂药物液态涂层后干燥成膜。综上,目前尚未见抗感染尿管专利转化应用于临床,相关研究多为实验室或动物实验阶段,中文抗感染尿管相关专利研究方式较为局限,研究水平亟待加强、深入。
[Abstract]:Background: Catheter-associated urinary tract infection is a difficult point in clinical diagnosis and treatment. The key to its pathogenesis lies in the formation of bacterial biofilm on the surface of materials. Objective: to review the patent status of anti-infective urinary catheter in China. Methods: using http://www.google.com/advanced_patent_search as the retrieval platform, the retrieval was carried out by "return the patent with the following patent name: urethra", and search up to 2014-03-26. Results & conclusion: a total of 949 results were obtained in the initial examination, excluding the unrelated patents and including only a clear statement of the anti-infective or antibacterial urethral catheter patents. A total of 23 Chinese patent results were included in the analysis. The results showed that the antimicrobial coating drug selection: most patents were nano-inorganic metal ion antimicrobial agents, Only 4 drug coatings containing antibiotic coating .2: mostly multilayer / composite coating .3 drug release mode: most patents stated as slow release, But the release controllability is not accounted for. 4 the preparation process: 1 patent adopts chemical bond or ion bond binding mode 2 items adopt blending method 1 item adopts coating and 1 item uses high voltage electrostatic spinning technique 12 items (52.17%) states that physical impregnation is adopted. Method .5 Antimicrobial method: 1 is ultrasonic antibacterial, 1 is aseptic sleeve, 1 is hydrophilic coating, 1 is anti-infective agent mixed with high molecular material to prepare conduit, The remaining 20 items (82.61%) were liquid coating containing antimicrobial agents and then dried to form film. To sum up, the patent conversion of anti-infective urethral tube has not been applied in clinic, the related research is mostly in laboratory or animal experiment stage, the research method of Chinese anti-infective urotubule patent is relatively limited, and the research level needs to be strengthened and deepened.
【作者单位】：四川省医学科学院四川省人民医院;电子科技大学附属医院泌尿外科;
【基金】：四川省科技厅科技支撑计划项目(2014RZ0032) 四川省医学甲级重点学科(泌尿外科)建设项目(2014年立项)~~
【分类号】：R318.08

【共引文献】