沙疗和热磁沙疗对兔子骨量变化及生物力学性能相关性研究

发布时间：2018-07-06 06:43

本文选题：沙疗 + 热磁沙疗　；参考：《新疆大学》2017年硕士论文

【摘要】：近年来治疗骨性关节炎(Osteoarthritis,OA)在临床医学领域上有了不少的成果。虽然治疗骨性关节炎的物理疗法的种类很多,但是各种治疗方法的机理也不同。其中,埋沙疗法是治疗效果最有效的方法之一,沙体成分里有很多种磁性矿物质,并且已有很多实践证明,各种磁疗仪在治疗骨疾病方面的治疗效果确实很好。我们考虑这些原因,将沙疗法和磁疗法结合起来,研究对骨性关节炎的治疗是否有耦合的积极作用,为临床邻域提供实验依据。股骨是承受动物身体载荷的主要构架,骨体积跟骨组织的功能和力学性能有密切的关系,所以本文主要分析了两种治疗法对软质骨、密质骨和硬质骨的骨量变化和它们之间的互相转变及生物力学性能之间的关系,及其进行多物理场仿真和模拟计算热场产生的热应力,并研究两种治疗的治疗效果对OA兔子的骨量变化及力学性能的机理。本实验选体重相近及健康的新西兰雄性大白兔为实验对象,实验对象适应新的环境后,实验对象关节腔注射浓度为3%的Papain蛋白水解酶的方法建立OA模型,然后随机分为沙疗组和热磁沙疗组。利用电子计算机断层扫描(CT)的技术获取兔子扫描数据,再利用医学影像控制系统(Mimics)处理CT扫描数据,获取股骨各股质层、肌肉和骨髓的体积及三维模型。通过做股骨的三点弯曲和压缩实验得到的力学性能指标及进行分析。实验结果显示兔子患OA后,比健康时软质骨的体积有了明显的上升,硬质骨的体积有了明显的下降,进行治疗后,发现软质骨的骨量逐渐减少,而硬质骨的骨量增多。通过对比两种治疗后CT扫描数据结果,沙疗组软质骨的骨量的减少量和硬质骨骨量的增多量明显大于热磁沙疗组软质骨骨量的减少量和硬质骨骨量的增多量,完成相关的生物力学实验后,发现沙疗组的生物力学指标同样大于热磁沙疗组。利用多物理场软件对OA模型进行生物传热数值模拟。热场产生的热应力改善了股骨力学功能的适应性及促进了骨重建。我们最终得出的结论是:虽然两种治疗对OA兔子有了缓解作用,但是沙疗比热磁沙疗的效果更明显,原因很可能是我们的热磁沙疗仪未能使热场和磁场结合一起,从而热磁沙疗组对OA兔子产生了消极作用。
[Abstract]:In recent years, the treatment of osteoarthritis (OA) has made a lot of achievements in the field of clinical medicine. Although there are many types of physiotherapy for osteoarthritis, the mechanisms of various treatments vary. Sand burying therapy is one of the most effective methods to treat bone diseases. There are many kinds of magnetic minerals in sand body. We consider these reasons and combine sand therapy with magnetic therapy to study whether there is a positive coupling effect on the treatment of osteoarthritis and provide experimental basis for clinical neighborhood. Femur is the main frame to bear animal body load. The function and mechanical properties of bone volume and calcaneal tissue are closely related, so this paper mainly analyzes the effect of two kinds of therapy on soft bone. The changes in bone mass of dense and hard bones and the relationship between their intertransformation and biomechanical properties, as well as the simulation and simulation of the thermal stresses generated by the thermal fields, The effects of two treatments on bone mass and mechanical properties of OA rabbits were studied. In this experiment, New Zealand male rabbits with similar weight and healthy weight were selected as experimental objects. After the subjects were adapted to the new environment, the OA model was established by injecting 3% Papain protein hydrolase into the articular cavity of the experimental subjects. Then they were randomly divided into sand therapy group and thermomagnetic sand therapy group. The scanning data of rabbits were obtained by computer tomography (CT), and the CT scanning data were processed by medical image control system (Mimics) to obtain the volume and 3D model of femoral layer, muscle and bone marrow. The mechanical properties of femur were analyzed by three-point bending and compression tests. The results showed that the volume of soft bone increased obviously and the volume of hard bone decreased obviously. After treatment, it was found that the amount of soft bone decreased gradually, but the amount of hard bone increased. By comparing the CT scan data after two kinds of treatments, the reduction of soft bone and the increase of hard bone in sand treatment group were obviously larger than those of soft bone and rigid bone in thermomagnetic sand treatment group. After completing the related biomechanical experiments, it was found that the biomechanical indexes of the sand therapy group were also higher than those of the thermomagnetic sand therapy group. The biological heat transfer of OA model was simulated by multi-physical field software. Thermal stress induced by thermal field improves the adaptability of femur mechanical function and promotes bone reconstruction. We finally concluded that although the two treatments had a palliative effect on OA rabbits, sand therapy was more effective than thermomagnetic sand therapy, probably because our thermomagnetic sand therapy instrument failed to combine the thermal field with the magnetic field. Thus the thermomagnetic sand therapy group had a negative effect on OA rabbits.
【学位授予单位】：新疆大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R684.3;R318.01

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