血流对HIFU肿瘤治疗影响的数值仿真研究
发布时间：2018-07-13 13:44
【摘要】：在高强度聚焦超声治疗肿瘤问题的研究中,高强度聚焦超声(high-intensity focused ultrasound,HIFU)治疗大血管周边的肝肿瘤时,血流对HIFU形成可治疗焦域的影响难以预测和实时监控,可能导致肿瘤组织残留或者血管的损伤等临床治疗问题。为了预测大血管对HIFU肝肿瘤治疗的影响,以HIFU治疗血管周边肿瘤为例建立三维仿真模型,利用Westervelt声传播方程及Pennes生物热传导方程,用时域有限差分法数值仿真HIFU治疗形成的温度场。仿真结果表明,当大血管位于目标治疗区域附近时,血管位置对60℃以上可治疗焦域的形状、大小及位置均有显著影响,但血流速度的影响很小。而当血管位于目标治疗区域内部时,血流速度对可治疗焦域的影响不可忽略。上述研究结果可为HIFU实际临床治疗提供理论数据和参考依据。
[Abstract]:In the study of high intensity focused ultrasound (HIFU) in the treatment of liver tumors around large vessels, the effect of blood flow on the formation of focal areas is difficult to predict and monitor in real time. May lead to tumor tissue residues or vascular injury and other clinical treatment problems. In order to predict the effect of large blood vessels on the treatment of HIFU liver tumors, a three-dimensional simulation model was established by using the Westervelt acoustic propagation equation and Pennes biothermic conduction equation. The temperature field of HIFU was numerically simulated by finite difference time domain (FDTD) method. The simulation results show that when the large blood vessel is located near the target therapeutic area, the position of the vessel has a significant effect on the shape, size and location of the treatable focal region above 60 鈩，
本文编号：2119570
[Abstract]:In the study of high intensity focused ultrasound (HIFU) in the treatment of liver tumors around large vessels, the effect of blood flow on the formation of focal areas is difficult to predict and monitor in real time. May lead to tumor tissue residues or vascular injury and other clinical treatment problems. In order to predict the effect of large blood vessels on the treatment of HIFU liver tumors, a three-dimensional simulation model was established by using the Westervelt acoustic propagation equation and Pennes biothermic conduction equation. The temperature field of HIFU was numerically simulated by finite difference time domain (FDTD) method. The simulation results show that when the large blood vessel is located near the target therapeutic area, the position of the vessel has a significant effect on the shape, size and location of the treatable focal region above 60 鈩，
本文编号：2119570
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