静电纺丝制备聚维酮碘纳米纤维作为新型创面敷料的性能研究

发布时间：2018-07-26 19:36

【摘要】：目的:制备聚维酮碘(polyvinylpyrrolidone iodine,PVP-I2)静电纺丝纳米纤维并对其作为新型创面敷料的性能进行研究。方法:以I2为模型药物,PVP为载体材料制备电纺纳米纤维。以溶液可纺性、喷丝速率、电纺丝形态等为指标,筛选最优处方及工艺条件并用扫描电镜和红外光谱进行表征。用紫外分光光度仪测定纳米纤维含量;考察纳米纤维的透气性及其对金葡菌、大肠杆菌、绿脓杆菌和肺炎链球菌的抑菌效果;建立大鼠皮肤创面模型,考察纳米纤维对创面的促愈作用。结果:PVP-I2纳米纤维最优处方和工艺条件为40%PVP,30%I2,纺丝电压15 k V,流速0.3 ml/h,接收距离15 cm;所得纳米纤维结构均匀,表面光滑;具备良好的抑菌作用;透气性优于无纺布(P=0.005);对创面的愈合有促进作用。结论:制备的PVP-I2纳米纤维载药均匀,抑菌作用强,透气性好,促愈作用优良,具有被开发为新型创面敷料的潜力。
[Abstract]:Aim: to prepare polyvinylpyrrolidone iodine PVP-I2 nanofibers and study their properties as new wound dressings. Methods: electrospun nanofibers were prepared with I _ 2 as model drug and PVP as carrier. The spinnability of solution, spinneret rate and electrospinning morphology were taken as the indexes. The optimum formulation and technological conditions were selected and characterized by scanning electron microscopy and infrared spectroscopy. The content of nanofibers was determined by ultraviolet spectrophotometer, the permeability of nanofibers and its bacteriostasis against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Streptococcus pneumoniae were investigated. To investigate the effect of nanofibers on wound healing. Results the optimum formulation and technological conditions of the nanofibers were as follows: 40 PVP 30i 2, 15 kV spinning voltage, 0.3 ml / h flow rate, 15 cm receiving distance, the structure of the nanofibers was uniform, the surface was smooth, and the nanofibers had good bacteriostatic effect. Air permeability was better than non-woven cloth (P0. 005), and it could promote wound healing. Conclusion: the prepared PVP-I2 nanofibers have the advantages of uniform drug loading, strong bacteriostatic effect, good permeability and good healing effect, and have the potential to be developed as a new wound dressing.
【作者单位】：重庆医科大学药学院药剂学教研室;第三军医大学大坪医院野战外科研究所药剂科;
【基金】：重庆市应用开发计划资助项目(编号:CSTC2014yykf A110022)
【分类号】：R318.08

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