液氮低温微创冷刀系统的设计与实验研究
发布时间：2018-07-28 10:57
【摘要】：低温微创疗法治疗肿瘤以其良好的治疗效果和巨大的应用前景正在受到越来越多的重视。目前广泛使用的冷冻治疗设备中，氩氦冷冻治疗系统和其他相变冷冻治疗设备在都存在着某些方面的局限性，从而限制了这种优良的肿瘤治疗方法的发展和应用。本文的研究内容正是为克服这种局限性而提出，旨在开发出一款基于液氮的制冷温度低、冷冻速度快、手术创口小、运行成本低、操作简便的微创冷刀治疗系统。 作为冷刀治疗系统前期研究的重要内容，本文将在冷刀系统软硬件设计、离体组织的冷冻实验、冷冻治疗过程中组织温度场分布等方面进行深入研究： ①根据微创冷刀系统监测和控制的需要，设计系统工作过程中的温度实时检测和显示模块，并在现有条件下，对该模块的功能进行实验验证；同时，研究冷热交替治疗过程中，冷冻过程和复温过程的温度控制策略； ②利用自主研究的冷刀系统，搭建实验平台，进行离体猪肝的冷冻实验，收集动物组织冷冻过程中的温度数据，分析其温度场的变化规律； ③在对生物传热学和生物传热模型进行梳理研究的基础上，根据对离体猪肝组织进行冷冻的实验事实，选择建立离体猪肝组织合适的物理模型和数学模型，并运用FLUENT有限元分析软件，进行冷冻过程中猪肝组织内温度场分布的数值模拟，，对数值模拟所采用的组织的热物性参数进行深入研究。 本文为液氮微创冷刀系统后续研究的开展奠定了基础。
[Abstract]:Low temperature minimally invasive therapy for cancer is being paid more and more attention for its good therapeutic effect and great potential application. There are some limitations in the argon helium cryotherapy system and other phase change cryotherapy equipment in the widely used cryotherapy equipment, which restricts the excellent treatment of tumor. In order to overcome this limitation, the purpose of this study is to develop a minimally invasive cold knife treatment system based on low cooling temperature, fast freezing speed, small operation cost, low operation cost and easy operation.
As an important part of the early research of the cold knife treatment system, this paper will make a thorough study on the hardware and software design of the cold knife system, the freezing experiment of the tissue in vitro and the distribution of the temperature field in the process of freezing treatment.
According to the needs of the monitoring and control of the minimally invasive cold knife system, the temperature real-time detection and display module in the working process of the system is designed, and the function of the module is tested under the existing conditions. At the same time, the temperature control strategy of the freezing process and the rewarming process is studied in the process of alternating cold and heat treatment.
The experiment platform was built by using the independent cold knife system, the freezing experiment of pig liver in vitro was carried out, the temperature data during the freezing process of animal tissues were collected, and the change law of the temperature field was analyzed.
(3) on the basis of the study of biological heat transfer and biological heat transfer model, according to the experimental facts about the freezing of pig liver tissue in vitro, a suitable physical model and mathematical model of the isolated pig liver tissue is chosen, and the numerical model of the temperature field distribution in the liver tissues of the pig's liver during the freezing process is carried out by using the FLUENT finite element analysis software. The thermal physical parameters of the structure adopted in numerical simulation are studied in depth.
This study laid the foundation for the follow-up study of the liquid nitrogen minimally invasive cold knife system.
【学位授予单位】：重庆大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.6
本文编号：2149890
[Abstract]:Low temperature minimally invasive therapy for cancer is being paid more and more attention for its good therapeutic effect and great potential application. There are some limitations in the argon helium cryotherapy system and other phase change cryotherapy equipment in the widely used cryotherapy equipment, which restricts the excellent treatment of tumor. In order to overcome this limitation, the purpose of this study is to develop a minimally invasive cold knife treatment system based on low cooling temperature, fast freezing speed, small operation cost, low operation cost and easy operation.
As an important part of the early research of the cold knife treatment system, this paper will make a thorough study on the hardware and software design of the cold knife system, the freezing experiment of the tissue in vitro and the distribution of the temperature field in the process of freezing treatment.
According to the needs of the monitoring and control of the minimally invasive cold knife system, the temperature real-time detection and display module in the working process of the system is designed, and the function of the module is tested under the existing conditions. At the same time, the temperature control strategy of the freezing process and the rewarming process is studied in the process of alternating cold and heat treatment.
The experiment platform was built by using the independent cold knife system, the freezing experiment of pig liver in vitro was carried out, the temperature data during the freezing process of animal tissues were collected, and the change law of the temperature field was analyzed.
(3) on the basis of the study of biological heat transfer and biological heat transfer model, according to the experimental facts about the freezing of pig liver tissue in vitro, a suitable physical model and mathematical model of the isolated pig liver tissue is chosen, and the numerical model of the temperature field distribution in the liver tissues of the pig's liver during the freezing process is carried out by using the FLUENT finite element analysis software. The thermal physical parameters of the structure adopted in numerical simulation are studied in depth.
This study laid the foundation for the follow-up study of the liquid nitrogen minimally invasive cold knife system.
【学位授予单位】：重庆大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.6
【引证文献】
相关期刊论文 前1条
1 王震;田学隆;倪润明;童明伟;王槐志;;液氮冷冻刀温度检测与显示系统实现[J];低温与超导;2013年11期
相关硕士学位论文 前3条
1 赵艳哲;低温冷冻皮肤疾病治疗过程建模及自动喷射系统研究[D];山东大学;2015年
2 张颖慧;冷热循环肿瘤治疗设备的控制系统工程化设计与实现[D];重庆大学;2015年
3 王震;液氮低温微创冷冻刀设计与实验研究[D];重庆大学;2014年
本文编号：2149890
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