高温退火氧化钛粉末的血液相容性实验研究
发布时间：2018-08-02 09:03
【摘要】：利用真空高温退火技术制备不同退火温度的Ti-O粉末、X线衍射仪、Zeta电位和比表面积等表征材料,采用Bradford法测纤维蛋白原在其表面的吸附解吸附行为,运用红外线光谱分析纤维蛋白原在其表面吸附后二级结构的变化,用流式细胞仪研究其对血小板的激活程度.研究表明,800℃高温退火使得Ti-O粉末由锐钛矿转化为金红石,比表面积减少10倍,携带有更多的负电荷;吸附血浆纤维蛋白原的数量减少到67μg,且维持原有的二级结构,并存在较大的解吸附;不易引起血小板的激活,具有更好的血液相容性.
[Abstract]:Ti-O powder X-ray diffractometer with different annealing temperature was prepared by vacuum high temperature annealing. The adsorption and desorption behavior of fibrinogen on its surface was measured by Bradford method. The changes of the secondary structure of fibrinogen adsorbed on the surface of fibrinogen were analyzed by infrared spectroscopy, and the activation degree of fibrinogen on platelets was studied by flow cytometry. The results showed that the Ti-O powder changed from anatase to rutile after high temperature annealing at 800 鈩，
本文编号：2158930
[Abstract]:Ti-O powder X-ray diffractometer with different annealing temperature was prepared by vacuum high temperature annealing. The adsorption and desorption behavior of fibrinogen on its surface was measured by Bradford method. The changes of the secondary structure of fibrinogen adsorbed on the surface of fibrinogen were analyzed by infrared spectroscopy, and the activation degree of fibrinogen on platelets was studied by flow cytometry. The results showed that the Ti-O powder changed from anatase to rutile after high temperature annealing at 800 鈩，
本文编号：2158930
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