MGF-Ct24E功能化聚乳酸仿生骨基质材料的制备与表征
发布时间：2018-08-04 18:26
【摘要】：以羟基磷灰石(HAP)表面羟基为引发基团,通过开环聚合法将丙交酯以共价化学键的方式接枝到HAP表面,得到PLA-g-HAP;再引入具有良好细胞相容性的马来酸酐和具有良好骨诱导性的力生长因子(MGF-Ct24E),得到MGF-Ct24E-MPLA-g-HAP。借助红外光谱分析、氨基酸分析、热性能分析、力学性能分析和电镜分析,对上述材料的结构及性能进行了表征。结果表明,最终产物中MGF-Ct24E的接枝率为22.63%,玻璃化转变温度为58.62℃,力学性能有明显增强,并具备了三维互通孔状结构和骨诱导生物活性。该材料有望作为新型仿生骨基质材料得到应用。
[Abstract]:Hydroxyapatite (HAP) surface hydroxyl group was used to graft lactide onto HAP surface by ring-opening polymerization. PLA-g-HAPs were obtained, and MGF-Ct24E-MPLA-g-HAPs were obtained by introducing maleic anhydride with good cytocompatibility and force growth factor (MGF-Ct24E) with good bone induction. The structure and properties of the materials were characterized by infrared spectroscopy, amino acid analysis, thermal performance analysis, mechanical property analysis and electron microscope analysis. The results show that the grafted ratio of MGF-Ct24E in the final product is 22.63 and the glass transition temperature is 58.62 鈩，
本文编号：2164726
[Abstract]:Hydroxyapatite (HAP) surface hydroxyl group was used to graft lactide onto HAP surface by ring-opening polymerization. PLA-g-HAPs were obtained, and MGF-Ct24E-MPLA-g-HAPs were obtained by introducing maleic anhydride with good cytocompatibility and force growth factor (MGF-Ct24E) with good bone induction. The structure and properties of the materials were characterized by infrared spectroscopy, amino acid analysis, thermal performance analysis, mechanical property analysis and electron microscope analysis. The results show that the grafted ratio of MGF-Ct24E in the final product is 22.63 and the glass transition temperature is 58.62 鈩，
本文编号：2164726
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