抗菌型BIS-GMA复合牙科材料的制备与表征
发布时间：2018-08-29 12:28
【摘要】：复合牙科材料是指一种由基体树脂和无机填料以及引发体系等混合均匀后固化而成的牙科材料。20世纪60年代双酚A甲基丙烯酸缩水甘油酯(Bis-GMA)逐渐成为一种常用的牙科复合材料基体树脂。但牙科修复材料与牙齿之间的裂痕,以及细菌在牙科修复体上的滋生,导致了继发龋的出现和牙髓的损坏。因此,具有抗菌功能的牙科修复材料有良好的应用前景。 本文以Bis-GMA和双甲基丙烯酸二缩三乙二醇酯(TEGDMA)为树脂基体,纳米8i02为无机填料,用甲基丙烯酸缩水甘油酯(GMA)对具有高效广谱抗菌性能的聚六亚甲基胍盐酸盐(PHMG)进行端基修饰,使其带上具有反应活性的C=C双键。然后分别使用化学固化和紫外固化法制备了牙科复合树脂,并对复合树脂的抗菌性能、力学性能和固化情况进行了考察。 分别采用马来酸酐(MAH)和甲基丙烯酸缩水甘油酯(GMA)对PHMG的端基进行修饰。通过红外光谱和核磁共振氢谱分析了所得产物的结构及端基修饰情况。结果表明：MAH和GMA都可以对PHMG进行端基修饰。由于GMA修饰的PHMG更有利于牙科复合树脂的制备,因此主要采用GMA端基修饰的PHMG-GMA制备牙科复合树脂。 将PHMG-GMA、Bis-GMA、TEGDMA和Si02以及引发剂以适当的比例调配,然后进行固化。用偶氮二异丁腈(AIBN)作引发剂制得的复合树脂,PHMG-GMA的加入基本不影响复合材料的力学性能；8i02的加入会降低复合树脂的弯曲强度,但可以提高压缩强度和硬度。含1.0%PHMG-GMA的复合树脂具有非常优异的抗变形链球菌的能力,抗菌率达99.99%。以樟脑醌(CQ)为引发剂进行紫外光固化,同样也可以得到具抗菌功能的牙科复合树脂,对大肠杆菌的抗菌率在99.0%以上,显示了非常好的抗菌效果。
[Abstract]:Composite dental material is a kind of dental material which is cured by mixing matrix resin, inorganic filler and initiator system. In the 1960s, bisphenol A glycidyl methacrylate (Bis-GMA) gradually became a common kind of dental material. Dental composite matrix resin. But the cracks between dental restorations and teeth, as well as the growth of bacteria in dental restorations, lead to secondary caries and pulp damage. Therefore, dental restorative materials with antimicrobial function have a good application prospect. In this paper, Bis-GMA and diethylene glycol dimethacrylate (TEGDMA) were used as resin matrix, nanometer 8i02 was used as inorganic filler, glycidyl methacrylate (GMA) was used to modify polyhexamethylguanidine hydrochloride (PHMG), which had high antimicrobial activity. C C double bond with reactive activity was carried on it. Then the dental composite resin was prepared by chemical curing and UV curing, and the antibacterial properties, mechanical properties and curing conditions of the composite resin were investigated. The terminal groups of PHMG were modified by maleic anhydride (MAH) and glycidyl methacrylate (GMA). The structure and end-group modification of the products were analyzed by IR and NMR spectra. The results show that PHMG can be modified by GMA and GMA. Because GMA modified PHMG is more favorable to the preparation of dental composite resin, GMA terminal modified PHMG-GMA is mainly used to prepare dental composite resin. PHMG-GMA,Bis-GMA,TEGDMA, Si02 and initiator were prepared in an appropriate proportion and then solidified. The addition of PHMG-GMA to the composite resin prepared by using azodiisobutyronitrile (AIBN) as initiator has little effect on the mechanical properties of the composite material. The addition of 8i02 can decrease the bending strength of the composite resin, but it can improve the compressive strength and hardness of the composite resin. The composite resin containing 1.0%PHMG-GMA has excellent ability to resist streptococcus mutans and its antibacterial rate is 99.99%. The dental composite resin with antibacterial function can also be obtained by UV curing with camphor quinone (CQ) as initiator. The antibacterial rate against Escherichia coli is more than 99.0%, showing a very good antibacterial effect.
【学位授予单位】：华东理工大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08
本文编号：2211208
[Abstract]:Composite dental material is a kind of dental material which is cured by mixing matrix resin, inorganic filler and initiator system. In the 1960s, bisphenol A glycidyl methacrylate (Bis-GMA) gradually became a common kind of dental material. Dental composite matrix resin. But the cracks between dental restorations and teeth, as well as the growth of bacteria in dental restorations, lead to secondary caries and pulp damage. Therefore, dental restorative materials with antimicrobial function have a good application prospect. In this paper, Bis-GMA and diethylene glycol dimethacrylate (TEGDMA) were used as resin matrix, nanometer 8i02 was used as inorganic filler, glycidyl methacrylate (GMA) was used to modify polyhexamethylguanidine hydrochloride (PHMG), which had high antimicrobial activity. C C double bond with reactive activity was carried on it. Then the dental composite resin was prepared by chemical curing and UV curing, and the antibacterial properties, mechanical properties and curing conditions of the composite resin were investigated. The terminal groups of PHMG were modified by maleic anhydride (MAH) and glycidyl methacrylate (GMA). The structure and end-group modification of the products were analyzed by IR and NMR spectra. The results show that PHMG can be modified by GMA and GMA. Because GMA modified PHMG is more favorable to the preparation of dental composite resin, GMA terminal modified PHMG-GMA is mainly used to prepare dental composite resin. PHMG-GMA,Bis-GMA,TEGDMA, Si02 and initiator were prepared in an appropriate proportion and then solidified. The addition of PHMG-GMA to the composite resin prepared by using azodiisobutyronitrile (AIBN) as initiator has little effect on the mechanical properties of the composite material. The addition of 8i02 can decrease the bending strength of the composite resin, but it can improve the compressive strength and hardness of the composite resin. The composite resin containing 1.0%PHMG-GMA has excellent ability to resist streptococcus mutans and its antibacterial rate is 99.99%. The dental composite resin with antibacterial function can also be obtained by UV curing with camphor quinone (CQ) as initiator. The antibacterial rate against Escherichia coli is more than 99.0%, showing a very good antibacterial effect.
【学位授予单位】：华东理工大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08
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