MPEG-PLLGA多孔支架制备影响因素研究

发布时间：2018-09-01 12:59

【摘要】：采用热致相分离法制备了MPEG-PLLGA(单甲氧基聚乙二醇-聚左旋丙交酯乙交酯)多孔支架。讨论了丙交酯/乙交酯(LA/GA)配比、聚合物质量浓度、预冻温度等因素对支架的孔径、孔隙率和力学性能的影响。结果表明,当聚合物质量浓度为0.03g/mL时,不同n(LA)/n(GA)比的MPEG-PLLGA支架的孔形貌相差较大,而当聚合物质量浓度为0.04g/mL和0.05g/mL时,3种n(LA)/n(GA)比的MPEG-PLLGA支架的孔形貌和孔径没有明显差异,且在相同聚合物质量浓度下,随着n(LA)/n(GA)比升高,所得支架的压缩强度增大;随聚合物溶液质量浓度的提高,3种n(LA)/n(GA)比支架的孔隙率、孔径均呈变小趋势,压缩强度逐渐增大;随预冻温度的降低,所得支架的孔径、孔隙率逐渐变小,压缩强度逐渐增大。
[Abstract]:MPEG-PLLGA (monomethoxy polyethylene glycol-poly (levo-lactide) porous scaffolds were prepared by thermally induced phase separation. The effects of the ratio of lactide to glycolide (LA/GA), the mass concentration of polymer and the prefreezing temperature on the pore size, porosity and mechanical properties of the scaffold were discussed. The results show that when the polymer concentration is 0.03g/mL, the pore morphology of MPEG-PLLGA scaffolds with different n (LA) / n (GA) ratios is different, but the pore morphology and pore size of MPEG-PLLGA scaffolds with n (LA) / n (GA) ratio are not significantly different when the polymer concentration is 0.04g/mL and 0.05g/mL. At the same polymer concentration, the compressive strength of the scaffolds increases with the increase of n (LA) / n (GA) ratio, and with the increase of the mass concentration of polymer solution, the pore size and pore size of the three kinds of n (LA) / n (GA) scaffolds tend to decrease, and the compressive strength increases gradually. With the decrease of prefreezing temperature, the pore size and porosity of the scaffold become smaller and the compressive strength increases.
【作者单位】：山东省医疗器械研究所山东省医用高分子材料重点实验室;山东省生物药物研究院山东省生物药物重点实验室;
【基金】：山东省优秀中青年科学家科研奖励基金(BS2011YY050)
【分类号】：R318.08

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