制备生物可降解网状人工胸壁:性能及在胸壁缺损中的应用

发布时间：2018-10-23 16:17

【摘要】：背景:传统修复胸壁缺损的材料由于无法降解,需要长期留在体内且组织反应较大,并发症发生率较高,难以满足修复的需要。目的:制备生物可降解网状人工胸壁,分析其性能及在胸壁缺损中的应用效果。方法:将蚕丝纤维来源与聚己内酯熔融共混,制备生物可降解网状人工胸壁材料,检测其孔隙率与弹性模量。取22只家兔,建立胸壁缺损模型,随机分2组,实验组置入生物可降解网状人工胸壁材料,对照组置入聚己内酯材料,置入后4周,苏木精-伊红染色观察缺损部位;置入后2个月,CT检查骨缺损部位。结果与结论:(1)生物可降解网状人工胸壁材料孔洞分布较均匀,孔隙率为54.4%,直径200-300μm,材料中纤维分布相对稳定,弹性模量高于聚己内酯(P0.05);(2)CT显示,实验组材料与肋骨断端紧密接触,胸壁板与脏层胸膜之间出现新生组织;对照组材料与断端处接触,边界不清,存在高密度影;(3)苏木精-伊红染色显示,实验组有大量纤维细胞,胶原纤维较疏松,炎细胞数少;对照组纤维肌膜与肌肉边界不清,存在水肿,有较多炎细胞浸润;(4)结果表明:生物可降解网状人工胸壁可促进缺损胸壁的修复。
[Abstract]:Background: the traditional materials for the repair of chest wall defects need to remain in the body for a long time and have a large tissue reaction due to their non-degradability. The incidence of complications is high and it is difficult to meet the needs of repair. Objective: to prepare biodegradable reticular artificial chest wall and analyze its performance and application effect in chest wall defect. Methods: the silk fiber was blended with polycaprolactone to prepare biodegradable reticulated artificial chest wall material and its porosity and elastic modulus were measured. 22 rabbits were randomly divided into two groups: the experimental group was implanted with biodegradable reticular artificial chest wall and the control group was implanted with polycaprolactone. The defect site was observed by hematoxylin-eosin staining 4 weeks after implantation. Two months after implantation, the site of bone defect was examined by CT. Results and conclusion: (1) the pore distribution of biodegradable reticular artificial chest wall was uniform, the porosity was 54.4, the diameter was 200-300 渭 m, the fiber distribution was relatively stable, and the elastic modulus was higher than that of polycaprolactone (P0.05); (2) CT. The experimental group was in close contact with the broken end of rib. The new tissue appeared between the pleural wall and the visceral pleura; in the control group, the contact between the material and the broken end was not clear and there were high density shadows; (3) there were a large number of fibrous cells in the experimental group, the collagen fibers were loose, and the number of inflammatory cells was less; In the control group, the boundary between fibromyomembrane and muscle was not clear, there were edema and inflammatory cell infiltration. (4) the results showed that the biodegradable reticular artificial chest wall could promote the repair of the defect chest wall.
【作者单位】：南阳市中心医院;克拉玛依市中心医院;新疆医科大学第一附属医院;
【分类号】：R318.08;R655

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