硬组织植入生物活性聚醚醚酮复合材料

发布时间：2018-11-05 20:58

【摘要】：聚醚醚酮(PEEK)具有优良的机械性能、良好的生物相容性和耐腐蚀性等特点,其弹性模量和人体皮质骨较为接近,有可能替代金属材料应用在硬组织修复与替换领域。然而,PEEK本身是生物惰性材料,PEEK植入体与骨组织之间的骨整合能力较差,在一定程度上限制了其在硬组织修复与替换领域的应用。目前研究者主要将磷酸钙(CaP)、生物活性玻璃(BGs)和硅酸钙(CS)等生物活性陶瓷添加到PEEK基体中制备复合材料以改善其生物活性,提高PEEK植入体与骨组织之间的骨整合能力。但这些生物活性陶瓷在改善PEEK生物活性的同时,降低了其优异的力学性能。如何在保持PEEK力学性能的同时提高其生物活性成为目前研究的热点。本文综述了近些年用于硬组织植入的生物活性聚醚醚酮复合材料的制备技术、力学及生物学性能等方面的研究进展及现状,并对其发展提出了展望。
[Abstract]:Polyether ether ketone (PEEK) has excellent mechanical properties, good biocompatibility and corrosion resistance, and its elastic modulus is close to that of human cortical bone. It is possible to replace metal materials in the field of hard tissue repair and replacement. However, PEEK itself is a biological inert material, and the ability of bone integration between PEEK implants and bone tissues is poor, which limits its application in the field of hard tissue repair and replacement to some extent. At present, bioactive ceramics such as calcium phosphate (CaP), bioactive glass (BGs) and calcium silicate (CS) were added to PEEK matrix to prepare composites to improve their biological activity. To improve the ability of bone integration between PEEK implants and bone tissues. But these bioactive ceramics can improve the bioactivity of PEEK and decrease its excellent mechanical properties. How to maintain the mechanical properties of PEEK and improve its biological activity has become a hot topic. In this paper, the recent advances in the preparation, mechanical and biological properties of bioactive polyether ether ketone composites for hard tissue implantation are reviewed, and their development prospects are also presented.
【作者单位】：川北医学院基础医学院;中国科学院成都有机化学研究所;
【基金】：川北医学院博士基金项目(No.CBY16-QD-02) 中国科学院“西部之光”重点项目资助~~
【分类号】：R318.08;TB332

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