模拟体内应力作用的骨支架降解和骨重建仿真研究
发布时间：2018-11-15 11:21
【摘要】：目前对骨组织工程学的研究主要通过实验研究和数值模拟的方法进行。由于骨再生过程持续时间周期很长,基于体内试验的方法开展相关研究难于进行,且花费巨大。随着计算机计算能力的提高和新的数学理论的不断出现,利用数值模拟技术对骨组织工程进行相关研究的工作逐步深入。 本论文主要通过计算机仿真的手段对体内应力作用下的骨支架降解和骨重建的过程进行模拟研究。主要工作和成果如下： (1)构建了考虑应力影响因素的骨支架降解公式,利用多孔固体结构与性能理论建立起骨支架的弹性模量和支架壁厚之间的关系式,描述骨支架胞元的降解,得出每次降解骨支架的壁厚的变化量。 (2)利用应变能密度理论模拟伴随骨支架降解过程的骨再生过程。以参考应变能密度理论为基础,在计算应变能时综合考虑降解过程中新骨的生成对骨-支架系统的力学性能的影响,骨支架降解和新骨重建是两个独立,又相互影响的过程。 (3)应用有限元软件和子程序来模拟骨支架降解和骨再生的过程。利用骨支架胞元的变化刻画整体支架的变化,把有限元软件中的六面体单元和骨支架胞元相结合,以单元的力学性能的变化过程解释整个降解过程的发生。选取不同骨支架的初始孔径分别对上述过程进行计算,结果表明,随着孔径在一定范围内的增大,骨重建的情况越理想。 本论文建立的骨支架降解模型考虑了应力的影响,能够为受较大应力作用下的支架降解的情况做更清晰的描述。此外,论文中提出的以力学性能变化来刻画几何变化的仿真方法,在模拟过程中简化了大量的计算工作,可为以后相关的研究提供参考。
[Abstract]:At present, the research of bone tissue engineering is mainly carried out by experimental research and numerical simulation. Due to the long duration of bone regeneration, it is difficult and costly to carry out the research based on in vivo test. With the improvement of computer computing ability and the emergence of new mathematical theory, the research on bone tissue engineering by numerical simulation technology has been deepened step by step. In this paper, the process of bone scaffold degradation and bone reconstruction under stress in vivo was simulated by computer simulation. The main work and achievements are as follows: (1) the degradation formula of bone scaffold considering the factors of stress is constructed. The relationship between elastic modulus and wall thickness of bone scaffold is established by using the theory of porous solid structure and properties. The cell degradation of bone scaffold was described, and the change of wall thickness of bone scaffold was obtained. (2) the strain energy density theory was used to simulate the process of bone regeneration with the degradation of bone scaffolds. Based on the theory of reference strain energy density, the influence of the formation of new bone on the mechanical properties of bone scaffold system is considered synthetically in the calculation of strain energy. The degradation of bone scaffold and the reconstruction of new bone are two independent and interactive processes. (3) finite element software and subroutine were used to simulate the degradation and bone regeneration of bone scaffold. The change of bone scaffold cell is used to describe the change of the whole scaffold. The hexahedron element and bone scaffold cell in finite element software are combined to explain the whole degradation process with the change process of the mechanical properties of the unit. The process was calculated with the initial aperture of different bone scaffolds. The results show that with the increase of the pore diameter in a certain range, the better the situation of bone reconstruction. In this paper, the degradation model of bone scaffold takes into account the effect of stress, which can clearly describe the degradation of scaffold under high stress. In addition, the simulation method proposed in this paper to describe the geometric change with the change of mechanical properties simplifies a lot of calculation work, which can be used as a reference for the related research in the future.
【学位授予单位】：浙江工业大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08
本文编号：2333174
[Abstract]:At present, the research of bone tissue engineering is mainly carried out by experimental research and numerical simulation. Due to the long duration of bone regeneration, it is difficult and costly to carry out the research based on in vivo test. With the improvement of computer computing ability and the emergence of new mathematical theory, the research on bone tissue engineering by numerical simulation technology has been deepened step by step. In this paper, the process of bone scaffold degradation and bone reconstruction under stress in vivo was simulated by computer simulation. The main work and achievements are as follows: (1) the degradation formula of bone scaffold considering the factors of stress is constructed. The relationship between elastic modulus and wall thickness of bone scaffold is established by using the theory of porous solid structure and properties. The cell degradation of bone scaffold was described, and the change of wall thickness of bone scaffold was obtained. (2) the strain energy density theory was used to simulate the process of bone regeneration with the degradation of bone scaffolds. Based on the theory of reference strain energy density, the influence of the formation of new bone on the mechanical properties of bone scaffold system is considered synthetically in the calculation of strain energy. The degradation of bone scaffold and the reconstruction of new bone are two independent and interactive processes. (3) finite element software and subroutine were used to simulate the degradation and bone regeneration of bone scaffold. The change of bone scaffold cell is used to describe the change of the whole scaffold. The hexahedron element and bone scaffold cell in finite element software are combined to explain the whole degradation process with the change process of the mechanical properties of the unit. The process was calculated with the initial aperture of different bone scaffolds. The results show that with the increase of the pore diameter in a certain range, the better the situation of bone reconstruction. In this paper, the degradation model of bone scaffold takes into account the effect of stress, which can clearly describe the degradation of scaffold under high stress. In addition, the simulation method proposed in this paper to describe the geometric change with the change of mechanical properties simplifies a lot of calculation work, which can be used as a reference for the related research in the future.
【学位授予单位】：浙江工业大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08
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