用于心血管医疗装置的聚合物表面构建与生物相容性研究Ⅲ——聚合物生物材料表面的凝血及抗凝血涂层改性（英文）

发布时间：2018-11-24 18:02

【摘要】：背景:用于心血管医疗的生物材料在血液接触性条件下必须具有抗血栓性、对抗生物降解性与抗感染性。目的:研制用于心血管组织工程的新型植(介)入型聚合物材料(表面),从聚合物生物材料表面的凝血及抗凝血涂层改性方面考察各种相应改性表面的生物相容性、血液相容性和细胞相容性。方法:检索1983至2014年PubMed数据库及万方数据库。英文检索词为"biocompatibility,blood compatibility,biomedical materials,biomedical polymer materials",中文检索词为"生物相容性材料;血液相容性材料;生物医用材料;医用高分子材料"。排除与研究目的相关性差及内容陈旧、重复的文献,保留与生物医用高分子材料的血液相容性研究,进行归纳总结。结果与结论:通过对血液与植入物间的相互作用和生物材料表面的抗凝血涂层改性两个方面的归纳分析,从聚合物生物材料表面的凝血及抗凝血涂层改性方面考察了各种相应改性表面的生物相容性、血液相容性和细胞相容性。研制用于心血管组织工程的新型植(介)入型聚合物材料(表面)关键在于对聚合物生物材料表面的凝血及抗凝血涂层改性以及对其相应生物相容性与内皮细胞相容性的研究。通过对心血管医疗用聚合物生物材料的种类与应用及其心血管医疗器件和可植入性软组织替代物的深入研究可以发现表面与本体的差别则将体现在从表面向本体延伸的很多层分子上,而2种主要因素决定了其包括本体/表面差异及表面相分离在内的本体/表面行为,即表面能和分子运动性。如果考虑到对本体-表面的组成差异的理解,则还必须追加另以附加决定因素,即各组分的结晶行为。
[Abstract]:Background: biomaterials for cardiovascular medicine must have anti-thrombotic, anti-biodegradable and anti-infectious properties under blood contact conditions. Objective: to develop a new type of polymer material (surface) for cardiovascular tissue engineering, and to investigate the biocompatibility of various modified surfaces from the aspects of coagulation and anticoagulant coating modification on the surface of polymer biomaterials. Blood compatibility and cytocompatibility. Methods: PubMed database and Wanfang database were searched from 1983 to 2014. The English key word is "biocompatibility,blood compatibility,biomedical materials,biomedical polymer materials" and the Chinese key word is "biocompatibility material; blood compatibility material; biomedical material; medical polymer material". To eliminate the poor correlation with the purpose of the study and the contents of the obsolete, repetitive literature, research on the blood compatibility with biomedical polymer materials, summarized and summarized. Results & conclusion: the interaction between blood and implants and the modification of anticoagulant coating on the surface of biomaterials were summarized and analyzed. The biocompatibility, blood compatibility and cytocompatibility of various modified surfaces were investigated from the aspects of coagulation and anticoagulant coating modification of polymer biomaterials. The key to the development of new implant (intermediate) polymer materials (surfaces) for cardiovascular tissue engineering lies in the modification of coagulation and anticoagulant coatings on the surface of polymer biomaterials and the study of their corresponding biocompatibility with endothelial cell compatibility. Through the in-depth study of the types and applications of polymer biomaterials for cardiovascular medicine, as well as the cardiovascular medical devices and implantable soft tissue substitutes, it can be found that the difference between the surface and the body will be reflected from the surface to the body. On many layers of molecules that extend, Two main factors determine the bulk / surface behavior including bulk / surface difference and surface phase separation, that is, surface energy and molecular motility. If the understanding of ontology-surface composition difference is taken into account, additional determinants must be added, that is, the crystallization behavior of each component.
【作者单位】：呼伦贝尔学院科研处;浙江大学高分子科学研究所;Department
【分类号】：R318.08

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