3D打印应用在骨组织工程研究中的特点与进展

发布时间：2018-11-27 16:35

【摘要】：背景:3D打印能够根据患者不同组织器官的具体解剖数据,利用计算机设计构建个性化三维支架材料,快速精确的重建缺损组织/器官,如骨、软骨、肌肉、血管等,但在应用过程中也存在诸多未知问题。目的:通过查阅近年有关3D打印技术在骨组织工程领域的应用,在3D打印技术原理及分类、支架材料分类及特点及组织相容性等方面作总结,为构建组织工程骨的基础研究提供理论依据。方法:检索PubM ed数据库、中国知网数据库(CNKI)2001年1月至2017年1月发表有关3D打印技术在骨组织工程中应用的文献。以"快速成型、3D打印、骨组织工程"为检索词,排除重复性研究,选择具有代表性的30篇文献进行讨论、综述。结果与结论:3D打印支架材料可模仿正常组织微观结构,实现种子细胞、支架材料同步打印,实现种子细胞分化、生物材料降解同步进行并修复缺损部位组织。生物陶瓷具有良好的生物相容性及机械强度,已成为应用最广泛的骨组织工程支架材料,但组织工程骨血管生长、细胞信号传导仍亟待解决。
[Abstract]:Background: 3D printing can be used to construct personalized three-dimensional scaffold materials based on the anatomical data of different tissues and organs of patients, and to reconstruct defect tissues / organs quickly and accurately, such as bone, cartilage, muscle, blood vessels, etc. However, there are many unknown problems in the process of application. Objective: to review the application of 3D printing technology in bone tissue engineering in recent years, and summarize the principle and classification of 3D printing technology, classification and characteristics of scaffold materials and histocompatibility, etc. To provide a theoretical basis for the construction of tissue engineering bone. Methods: PubM ed database and (CNKI) database published from January 2001 to January 2017 were published on the application of 3D printing technology in bone tissue engineering. "Rapid prototyping, 3D printing, bone tissue engineering" as the key words, excluding repetitive research, select 30 representative literature for discussion, review. Results & conclusion: 3D printing scaffold can mimic the microstructure of normal tissue, realize seed cells, synchronously print scaffold materials, realize seed cell differentiation, synchronously degrade biomaterials and repair defect tissue. Bioceramics, with good biocompatibility and mechanical strength, have become the most widely used scaffold materials for bone tissue engineering. However, the vascular growth and cell signal transduction of tissue engineered bone still need to be solved.
【作者单位】：曲靖市第一人民医院骨一科;曲靖市第二人民医院病理科;
【基金】：云南省教育厅科学研究基金项目(2016ZDX074)~~
【分类号】：R318.08;R68

【相似文献】