基于可降解磷酸酯键的生物材料和药物缓释体系的研究

发布时间：2018-12-11 03:50

【摘要】：磷酸酯键是一种广泛存在于人体细胞和组织中的连接键,其不仅是卵磷脂的主要结构,更是核酸大分子DNA、RNA的组成部分。近年来,以磷酸酯键为连接键的材料的研究越来越受到科学工作者的重视,并证明其具有优异的降解性和生物相容性,并广泛的应用于组织工程和药物释放领域。 鉴于磷酸酯键的诸多优点,本论文设计并研究了以磷酸酯键为交联键的热固化可降解的生物弹性体材料。通过将低分子量聚乙二醇(PEG)进行环氧化和磷酸酯化修饰,按既定的比例将两者混合均匀,在50℃下固化5小时,形成以磷酸酯为交联键的三维网络结构交联材料。实验结果表明：(1)PEG的环氧化和磷酸化修饰制备简单、产率高、转化率高。(2)材料制备简单且周期短。(3)材料的力学性能与预聚物结构、配比等有直接关系。预聚物分子量越低,材料强度最高；且当P-OH基团和环氧基团比例为2：3时,材料强度最高。(4)材料具有良好的生物降解性,较低的细胞毒性和一定的药物缓释能力。 此外我们还设计了以磷酸酯键为连接键的药物载体体系：以含有环氧基团的高分子材料或无机材料为载体,通过与含有P-OH官能团的药物进行反应,制备以磷酸酯键为连接的载药体系。通过紫外和高效液相色谱测试初步表明,构建的两种载药体系都具有一定的药物缓释能力且具有一定药物释放选择性。
[Abstract]:Phosphate bond is a kind of connective bond which widely exists in human cells and tissues. It is not only the main structure of lecithin but also the component of nucleic acid macromolecule DNA,RNA. In recent years, more and more attention has been paid to the study of phosphate bonding materials, which has been proved to have excellent biodegradability and biocompatibility, and has been widely used in tissue engineering and drug release fields. In view of the many advantages of phosphate bond, the thermo-degradable bioelastic material with phosphate bond as crosslinking bond was designed and studied in this paper. The low molecular weight polyethylene glycol (PEG) was modified by epoxidation and phosphorylation, and the two materials were mixed uniformly at a fixed proportion and cured at 50 鈩，

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