可吸收缝线材料的可降解与临床应用
发布时间：2019-01-21 14:34
【摘要】：背景:由于可吸收缝合线具有良好的生物相容性及机械强度,在临床被广泛应用。目的:探讨不同可吸收性缝线的体外降解性能,分析可吸收缝合线临床应用中的优势及其体外降解行为的影响因素。方法:通过检索近年来文章内容与可吸收缝线材料降解性能和应用相关的文献,从可吸收缝线材料的性能及降解行为影响因素、可吸收与不可吸收缝合线临床应用比较等对可吸收缝线材料相关研究成果作回顾性分析,为临床提供理论依据。结果与结论:可吸收缝合线体可被机体完全降解吸收,无不良反应,创口愈合后不留瘢痕,克服了不可吸收缝合线不能在体内分解的缺点,其降解产物的体内吸收主要有2个途径:一为体内巨细胞与吞噬细胞吞噬,另一途径为降解产物进入人的体液与血液,如乳酸通过体循环被吸收排泄。人体内有一个极其复杂的生理环境,存在着影响材料性能的各种因素。加之材料的种类不同,它们在体内的降解行为也不尽相同,因此需要在一定范围内设计合成和加工出具有特殊性能的可降解高分子材料满足临床需要。
[Abstract]:BACKGROUND: The absorbable suture has good biocompatibility and mechanical strength and is widely used in clinic. Objective: To study the in vitro degradation of different absorbable sutures, and to analyze the advantages of absorbable suture in the clinical application and the influencing factors of in vitro degradation behavior. Methods: The properties of the suture material and the influencing factors of the degradation behavior of the absorbable suture material were analyzed by searching the literature related to the degradation performance and application of the absorbable suture material in recent years. The clinical application of absorbable and non-absorbable suture materials is analyzed retrospectively, and the theoretical basis for clinical application is provided. Results and Conclusion: The absorbable suture body can be completely degraded and absorbed by the body, no adverse reaction, no scar after the wound healing, and the defect that the non-absorbable suture cannot be decomposed in the body is overcome, and the in vivo absorption of the degradation product is mainly 2 routes: One is the in vivo giant cell and phagocyte phagocytosis, and the other route is to degrade the body fluid of the product into the human body and the blood, such as the lactic acid is absorbed and discharged through the body circulation. There is an extremely complex physiological environment in the human body, and there is a variety of factors that affect the performance of the material. In addition to the different kinds of materials, the degradation behavior in the body is different, so it is necessary to design and synthesize and process the degradable high-molecular material with special performance in a certain range to meet the clinical needs.
【作者单位】： 中国医科大学附属第四医院;
【分类号】：R318.08
[Abstract]:BACKGROUND: The absorbable suture has good biocompatibility and mechanical strength and is widely used in clinic. Objective: To study the in vitro degradation of different absorbable sutures, and to analyze the advantages of absorbable suture in the clinical application and the influencing factors of in vitro degradation behavior. Methods: The properties of the suture material and the influencing factors of the degradation behavior of the absorbable suture material were analyzed by searching the literature related to the degradation performance and application of the absorbable suture material in recent years. The clinical application of absorbable and non-absorbable suture materials is analyzed retrospectively, and the theoretical basis for clinical application is provided. Results and Conclusion: The absorbable suture body can be completely degraded and absorbed by the body, no adverse reaction, no scar after the wound healing, and the defect that the non-absorbable suture cannot be decomposed in the body is overcome, and the in vivo absorption of the degradation product is mainly 2 routes: One is the in vivo giant cell and phagocyte phagocytosis, and the other route is to degrade the body fluid of the product into the human body and the blood, such as the lactic acid is absorbed and discharged through the body circulation. There is an extremely complex physiological environment in the human body, and there is a variety of factors that affect the performance of the material. In addition to the different kinds of materials, the degradation behavior in the body is different, so it is necessary to design and synthesize and process the degradable high-molecular material with special performance in a certain range to meet the clinical needs.
【作者单位】： 中国医科大学附属第四医院;
【分类号】：R318.08
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