脉冲电磁场协同多孔钛合金对兔长骨缺损修复效果的微观结构分析

发布时间：2019-02-16 07:01

【摘要】：多孔钛合金(p Ti)是目前较为理想的骨替代修复材料,但其在微观水平上仍难以与骨组织充分骨整合。为此,研究了脉冲电磁场(PEMF)协同p Ti作用对兔长骨缺损的修复效果。采用电子束熔融技术制备孔隙率70%的Ti6Al4V多孔钛合金圆棒;于12只成年兔股骨外侧髁构建骨缺损,填充以p Ti,并采用自行研制的基于"3-Helm Holz线圈"的电磁发生系统产生2 m T、15 Hz的PEMF进行实验。结果表明:与单独的p Ti作用相比,在PEMF和p Ti的协同作用下,6周后,p Ti中的骨体积百分比提高了78.5%,骨小梁数量提高了21.7%,骨小梁厚度增大了41.8%,骨小梁间隙减小了30.7%,骨表面积密度减少了36.2%。因此,PEMF显著提高了p Ti的骨缺损修复效率,PEMF协同p Ti作用是一种更为高效的长骨缺损修复方法。
[Abstract]:Porous titanium alloy (p Ti) is an ideal bone replacement material at present, but it is still difficult to integrate fully with bone tissue at microcosmic level. The effect of pulsed electromagnetic field (PEMF) combined with p Ti on repairing rabbit long bone defect was studied. Ti6Al4V porous titanium alloy rod with 70% porosity was prepared by electron beam melting technique. A bone defect was constructed on the lateral femoral condyle of 12 adult rabbits. The bone defect was filled with p Ti, and the PEMF was produced by the electromagnetic generation system based on the "3-Helm Holz coil" for 2 t ~ 15 Hz. The results showed that the percentage of bone volume in, p Ti increased 78.5%, the number of trabecular bone increased 21.7% and the thickness of trabecular bone increased 41.8% in, p Ti after 6 weeks compared with p Ti alone, and the results showed that the percentage of bone volume in, p Ti increased by 78.5%, the number of trabecular bone increased by 21.7%, and the thickness of trabecular bone increased by 41.8%. Trabecular space decreased by 30.7 and bone surface density decreased by 36.2. Therefore, PEMF can significantly improve the repair efficiency of bone defect of p Ti. PEMF combined with p Ti is a more efficient method for repairing long bone defect.
【作者单位】：第四军医大学生物医学工程系;第四军医大学西京医院骨科;
【基金】：国家自然科学基金(81471806;31270889) 陕西省自然科学基金(2014JQ4139)~~
【分类号】：R683;R318.08

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