国产SWS-4000型血透机与进口金宝AK-200型血透机的临床对比研究

发布时间：2019-03-21 20:19

【摘要】：目的研究国产SWS-4000型血透机的治疗效果、安全性、稳定性。方法采用前瞻、开放、随机对照研究方法研究国产SWS-4000型血透机,以进口金宝AK-200型血透机为对照;以住院慢性肾功能衰竭新入透析患者为研究对象,在为期2年的观察期内,SWS-4000型血透机纳入507例(8 094人次),AK-200血透机纳入593例(8 150人次);观察近期、长期透析效果、透析并发症、机器配液等指标。结果治疗过程中不同血透机型患者低血压、高血压、胸闷、心悸、恶心、肌肉痉挛等发生率差异无统计学意义(P0.05);SWS-4000型血透机误超的离散度较大,水路报警较多,透析液钠离子浓度较高(P0.05),但可通过下调机器的电导设定值来纠正;采用SWS-4000型血透机单次透析后KT/V、尿素下降率(URR)、血钙、血磷、血钾、总CO2、血β2微球蛋白等指标的改善程度与AK-200型血透机差异无统计学意义(P0.05);采用SWS-4000型血透机维持性血透3个月时,患者的血红蛋白、清蛋白、甲状旁腺激素(PTH)、铁蛋白、转铁蛋白饱和度等指标,与AK-200型血透机差异无统计学意义(P0.05)。结论SWS-4000型透析机能满足日常血液透析工作需要,能安全有效地治疗尿毒症患者。
[Abstract]:Objective to study the therapeutic effect, safety and stability of domestic SWS- 4000 hemodialysis machine. Methods A prospective, open, randomized controlled study was used to study the domestic SWS- 4000 hemodialysis machine, and the imported Jinbao AK- 200 hemodialysis machine as the control. In the 2-year observation period, SWS- 4000 hemodialysis machine and AK-200 hemodialysis machine were included in 507 cases (8 094 person-times) and 593 cases (8 150 person-times) in the inpatients with chronic renal failure (CRF). Observation of the short-term, long-term dialysis effects, dialysis complications, machine fluid, and other indicators. Results there was no significant difference in the incidence of hypotension, hypertension, chest tightness, palpitation, nausea and muscle spasm among the patients with different hemodialysis models in the course of treatment (P0.05). The error dispersion of SWS- 4000 hemodialysis machine was larger, the alarm was more, and the concentration of sodium ion in dialysate was higher (P0.05), but it could be corrected by lowering the conductivity setting value of the machine. After single dialysis with SWS- 4000 hemodialysis machine, there was no significant difference between the improvement degree of (URR), blood calcium, blood phosphorus, blood potassium, total CO2, 尾 2 microglobulin and that of AK- 200 hemodialysis machine (P0.05). The patients' hemoglobin, albumin, parathyroid hormone (PTH), ferritin, transferrin saturation and so on were measured after 3 months of maintenance hemodialysis with SWS- 4000 hemodialysis machine, and the changes of hemoglobin, albumin, parathyroid hormone (PTH), ferritin and transferrin saturation were measured. There was no significant difference between the two groups (P0.05). There was no significant difference between the two groups (P0.05). Conclusion the dialysis function of SWS- 4000 can meet the needs of daily hemodialysis and can be used to treat uremic patients safely and effectively.
【作者单位】：第三军医大学新桥医院肾内科;
【基金】：重庆市科委重点攻关课题(CSTC,2010AA5043)
【分类号】：R197.39

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