机械力及力学信号转导影响干细胞命运的研究进展

发布时间：2019-04-23 20:57

【摘要】：干细胞作为一种未分化的祖细胞,目前已被广泛应用于开展组织损伤修复、再生以及干细胞特异谱系分化的研究.大量研究表明,干细胞所处的微环境对调控干细胞的生长和分化具有重要作用,多种溶液介质、细胞外基质和信号通路等参与了干细胞命运的调控.尽管已有大量研究证明,溶液介质(如激素和生长因子)在干细胞的生长和分化中发挥重要作用,但近年来越来越多的研究表明,机械力及力学信号转导同样在干细胞自我更新、分化、衰老和凋亡等细胞生理过程中起到重要的作用.本文将对机械应力响应的细胞基础、生物力学及力学信号调控干细胞自我更新和分化,以及生物力学调控干细胞命运可能的作用机制几个方面加以综述.
[Abstract]:As a kind of undifferentiated progenitor cells, stem cells have been widely used in tissue damage repair, regeneration and stem cell specific lineage differentiation. A large number of studies have shown that the microenvironment in which stem cells are located plays an important role in regulating the growth and differentiation of stem cells, and many kinds of solution media, extracellular matrix and signal pathway are involved in the regulation of stem cell fate. Although a large number of studies have shown that solution media (such as hormones and growth factors) play an important role in the growth and differentiation of stem cells, the more recent studies have shown that Mechanical and mechanical signal transduction also play an important role in the physiological processes of stem cells, such as self-renewal, differentiation, senescence and apoptosis. This article reviews the cellular basis of mechanical stress response, the self-renewal and differentiation of stem cells regulated by biomechanical and mechanical signals, and the possible mechanism of biomechanical regulation of stem cell fate.
【作者单位】：中国科学院动物研究所生殖生物学国家重点实验室;
【基金】：国家重点基础研究发展计划(批准号:2011CB710905) 中国科学院空间科学战略性先导科技专项(批准号:XDA04020202-20,XDA04020419)资助
【分类号】：R318.01

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