丝素蛋白应用于椎间盘纤维环组织工程的研究进展

发布时间：2019-06-25 21:34

【摘要】：[目的]综述国内外有关丝素蛋白应用于椎间盘纤维环组织工程的研究进展,为下一步的实验研究提供理论依据。[方法]广泛查阅近年来国内外有关丝素蛋白的研究成果,尤其是应用于椎间盘纤维环组织工程的相关文献,归纳总结其发展现状和研究进展。[结果]目前丝素蛋白提纯工艺已臻成熟,并且在多个领域得到应用,比如纤维环、软骨、肌腱、韧带组织工程和药物缓释材料等方面。以丝素蛋白为材料制成的支架,结构稳定,力学强度高,还具有良好的生物相容性和可控的生物降解速率,并且能够通过简单的化学修饰来改进各方面的性能。[结论]丝素蛋白作为椎间盘纤维环组织工程支架的理想材料,表现出了良好的发展前景,值得进一步研究和推广。
[Abstract]:[objective] to review the research progress of silk fibroin protein in intervertebral disc fiber ring tissue engineering at home and abroad, and to provide theoretical basis for further experimental research. [methods] the research results of silk fibroin protein at home and abroad in recent years were widely reviewed, especially the related literature applied to intervertebral disc fiber ring tissue engineering, and its development status and research progress were summarized. [results] at present, the purification process of silk fibroin protein has been mature and has been applied in many fields, such as fiber ring, cartilage, tendon, ligament tissue engineering and drug release materials. The scaffold made of silk fibroin has stable structure, high mechanical strength, good biocompatibility and controllable biodegradation rate, and can improve the properties of various aspects by simple chemical modification. [conclusion] Silk fibroin, as an ideal material for intervertebral disc fiber ring tissue engineering scaffold, has a good prospect of development and is worthy of further study and promotion.
【作者单位】：天津医科大学研究生院;天津市天津医院;
【基金】：国家自然科学基金资助项目(编号:31000432,81272046) 中国博士后科学基金资助项目(编号:2011M500530,2012T50235) 天津市卫生局科技基金重点资助项目(编号:2013KR16)
【分类号】：R318.08

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