敷料用海藻酸钙冻干膜的制备及性能研究

发布时间：2019-07-03 16:25

【摘要】：随着时代的发展和科技的进步,人们的资源危机意识和环境保护意识逐渐加深,越来越多的天然材料得到开发和使用。海藻酸盐因无毒副作用、具有优良的生物相容性、生物可降解性、无抗原体等特征,已被广泛应用于组织工程学及医学领域。本研究充分利用海藻酸盐优良的物理、化学及医用性能,采用冻干法制备敷料用海藻酸钙膜,探索可行的制备方法,优化制备工艺,并研究性能。冻干法制备的片层状海藻酸钙冻干膜疏松多孔,柔软有弹性,具有开放、贯通的片状结构。通过实验得出片层状海藻酸钙冻干膜的制备流程为：常温溶解—静置脱泡24h—低温冻结—真空冻干—5%氯化钙溶液交联—二次冻结—二次冻干通过测试海藻酸钙冻干膜的透气性、透湿性、机械性能和吸液性能,研究海藻酸钠溶解温度、脱泡方式及时间、海藻酸钠分子量、海藻酸钠溶液浓度以及分装量、氯化钙溶液浓度对海藻酸钙冻干膜性能的影响。通过对影响因素的分析,选择海藻酸钠分子量、海藻酸钠溶液浓度和分装量进行正交实验,确定最优工艺为：海藻酸钠粉末粘度600mPa.s、海藻酸钠溶液浓度2%、分装量20g/个,并得到透气性、透湿性、断裂强力、吸液性和保液性的一次线性回归方程。改变冻结条件制备了蜂窝状海藻酸钙冻干膜,并与片层状冻干膜对比分析,同时研究海藻酸钠溶液浓度对其性能的影响。对片层状和蜂窝状海藻酸钙冻干膜以及海藻酸钙无纺布对比分析,发现片层状海藻酸钙冻干膜的吸液保液率较低,蜂窝状海藻酸钙冻干膜的透气率偏小。
[Abstract]:With the development of the times and the progress of science and technology, people's awareness of resource crisis and environmental protection is gradually deepened, and more natural materials are developed and used. Alginate has been widely used in tissue engineering and medicine because of its no toxic and side effects, excellent biocompatibility, biodegradability, no resistance to chlamydia and so on. In this study, calcium alginate film for dressing was prepared by freeze-drying method, which made full use of the excellent physical, chemical and medical properties of alginate. The feasible preparation method was explored, the preparation process was optimized, and the properties were studied. The lamellar calcium alginate freeze-dried film prepared by freeze-drying method is loose and porous, soft and elastic, and has an open and through flake structure. The experimental results show that the preparation process of lamellar calcium alginate freeze-dried membrane is as follows: room temperature dissolution-static defoaming 24 h-low temperature freezing-vacuum freeze-drying-5% calcium chloride solution crosslink-secondary freezing-secondary freeze-drying by testing the air permeability, moisture permeability, mechanical properties and liquid absorption properties of calcium alginate freeze-dried membrane, and studying the dissolution temperature, defoaming mode and time of sodium alginate, and the molecular weight of sodium alginate. Effects of sodium alginate solution concentration, loading amount and calcium chloride solution concentration on the properties of calcium alginate freeze-dried membrane. Through the analysis of the influencing factors, the molecular weight of sodium alginate, the concentration of sodium alginate solution and the amount of sodium alginate solution were selected for orthogonal experiments. The optimum conditions were determined as follows: the viscosity of sodium alginate powder was 600mPa.s, the concentration of sodium alginate solution was 2%, and the linear regression equation of air permeability, moisture permeability, breaking strength, liquid absorption and liquid retention was obtained. Honeycomb calcium alginate freeze-dried membrane was prepared by changing freezing conditions and compared with lamellar freeze-dried film. The effect of sodium alginate solution concentration on its properties was also studied. The comparison and analysis of layered and honeycomb calcium alginate lyophilized membrane and calcium alginate non-woven fabric showed that the liquid retention rate of lamellar calcium alginate freeze-dried membrane was lower than that of honeycomb calcium alginate freeze-dried membrane.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R318.08

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