Mesoporous Bioglass/Silk Fibroin Scaffolds as a Drug Deliver

发布时间：2021-02-26 02:53

　　The potential of combining bioactive glass（MBG） and silk fibroin（SF） together as a new drug delivery system was evaluated. The three-dimensional porous scaffolds were selected as the form of SF, and sol-gel method was adopted to fabricate MBG in this study. The characteristic of the synthesized material was measured by transmission electron microscopy and scanning electron microscopy. In vitro evaluation of drug delivery was carried out in terms of drug loading and drug release. And aspirin was ... 

【文章来源】：Journal of Wuhan University of Technology（Materials Science Edition）. 2014,29(02)

【文章页数】：6 页

【文章目录】：
1 Introduction
2 Experimental
    2.1 Synthesis and characterization of MBG powders
    2.2 Preparation of silk, MBG/silk and scaffolds
    2.3 Characterization of silk, MBG/silk and scaffolds
    2.4 Cell culture and proliferation on scaffolds
    2.5 SEM examination
    2.6 In vitro drug loading and release
        2.6.1 Drug loading
        2.6.2 In vitro drug release
    2.7 Animals and surgical protocols
        2.7.1 Animals and surgical preparation
        2.7.2 Calvarial defects models and scaffold transplantation
    2.8 Microcomputed tomography （lCT）
    2.9 Statistical analysis
3 Results and discussion
    3.1 Characterization of the silk and MBG/silk scaffolds
    3.2 In vitro drug loading and release
        3.2.1 Drug loading efficiency
        3.2.2 In vitro drug release
    3.3 mCT analysis of the osteogenesis
4 Conclusions



本文编号：3051958