青光眼患者角膜中央厚度与眼压关系的Meta分析（英文）

发布时间：2017-12-28 07:35

本文关键词：青光眼患者角膜中央厚度与眼压关系的Meta分析（英文）　出处：《国际眼科杂志》2016年10期 　论文类型：期刊论文

【摘要】：目的:系统回顾正常人群和青光眼患者中央角膜厚度与眼压的研究资料,探讨两者之间的关联与机制。方法:在MEDLINE数据库和Science Direct数据库搜索有关角膜中央厚度与眼压关系的研究资料。另外在南方医科大学外文科部搜索2004/2006"眼科年刊"期刊。搜索关键词包括:角膜中央厚度、眼压、青光眼、高眼压症、剥脱青光眼、压平眼压计、厚度测量法、原发性开角青光眼、Goldmann压平眼压计。应用以下排除标准:1)非英语文献研究;2)在2005年以前的研究;3)案例性研究和案例点评性研究;4)与治疗方案或外科手术技术有关的研究;5)将青光眼与其他疾病,如糖尿病、高血压、心血管疾病来比,作为辅助变量;6)儿童作为研究对象的研究;7)动物作为研究对象的研究。结果:搜索产生了13项研究,包括12个观察性研究和1个病例对照研究。与对照组相比,青光眼患者眼压水平明显升高(SMD:0.50,95%CI:0.30~0.70,Z=4.88,P0.001);青光眼组患者角膜中央厚度水平有明显降低(SMD:-0.14,95%CI:-0.23~-0.05,Z=3.14,P=0.002)。Meta-回归分析结果显示年龄跟两个组之间观察到的CCT差异有统计学意义(P=0.025)。结论:与正常眼组相比,青光眼组患者表现为角膜中央厚度变薄和眼压增高。
[Abstract]:Objective: To review the research data of the central corneal thickness and intraocular pressure in normal and glaucoma patients, and to explore the relationship and mechanism between them. Methods: to search the data about the relationship between the central corneal thickness and intraocular pressure in the MEDLINE database and the Science Direct database. In the Foreign Language Department of Southern Medical University 2004/2006 "annual ophthalmology journals. Search keywords include central corneal thickness, intraocular pressure, glaucoma, ocular hypertension, exfoliative glaucoma, applanation tonometer, thickness measurement, primary open-angle glaucoma and Goldmann applanation tonometer. The application of the following exclusion criteria: 1) non English literature research; 2) a previous study in 2005; 3) case study and case study research; 4) research related to treatment or surgery; 5) the glaucoma and other diseases, such as diabetes, hypertension, cardiovascular disease, as the auxiliary variable; 6) of children as the research object of study; 7) animal as the research object of study. Results: the search resulted in 13 studies, including 12 observational studies and 1 case-control studies. Compared with the control group, the intraocular pressure level of glaucoma patients increased significantly (SMD:0.50,95%CI:0.30~0.70, Z=4.88, P0.001), and the central corneal thickness of glaucoma group was significantly decreased (SMD:-0.14,95%CI:-0.23~-0.05, Z=3.14, P=0.002). The results of Meta- regression analysis showed that there was significant difference in the CCT difference between age and two groups (P=0.025). Conclusion: compared with the normal eye group, the patients in the glaucoma group showed the thinning of the central corneal thickness and the increase of the intraocular pressure.
【作者单位】：中国广东省广州市南方医科大学南方医院眼科;
【基金】：National Natural Science Foundation of China(No.81170887) Horizontal Topic Matching Funds of Nanfang Hospital of Southern Medical University(No.G201202)~~
【分类号】：R775
【正文快照】： Citation:Bbumelo L.L,Bai L.The relationship between central corneal thickness and intraocular pressure in healthy and glaucomatous eyes,a systematic review and Meta-analysis.Guoji Yanke Zazhi(Int Eye Sci)2016;16(10):1783-1788 INTRODUCTION and character

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