Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌中的表达及意义

发布时间：2017-12-28 21:29

本文关键词：Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌中的表达及意义　出处：《临床耳鼻咽喉头颈外科杂志》2016年07期 　论文类型：期刊论文

更多相关文章：鼻腔鼻窦癌 鳞状细胞 Survivin Bcl-

【摘要】：目的:探讨凋亡相关蛋白Survivin及Bcl-2在鼻腔鼻窦鳞状细胞癌(SNSCC)中的表达及临床意义。方法:采用免疫组织化学Envision二步法检测35例SNSCC及20例正常下鼻甲黏膜标本中Survivin和Bcl-2的表达。结果:Survivin在SNSCC组织中的表达为88.6%,在正常下鼻甲黏膜组织无表达,二者差异有统计学意义(P0.01)。Bcl-2在SNSCC组织中的表达为71.4%,明显高于正常下鼻甲黏膜组织的表达25%(P0.01)。Survivin与Bcl-2的表达呈正相关(P0.01)。肿瘤的分级程度越高,Survivin和Bcl-2的表达水平越低。结论:Survivin、Bcl-2与SNSCC的发生、发展有关,Survivin可能会成为SNSCC基因治疗的靶点。
[Abstract]:Objective: To investigate the expression of apoptosis related protein Survivin and Bcl-2 in nasal sinus squamous cell carcinoma (SNSCC) and its clinical significance. Methods: immunohistochemical Envision two step method was used to detect the expression of Survivin and Bcl-2 in 35 cases of SNSCC and 20 cases of normal inferior turbinate mucous membrane. Results: the expression of Survivin in SNSCC tissue was 88.6%, and there was no expression in normal inferior turbinate mucosa, and the difference between the two groups was statistically significant (P0.01). The expression of Bcl-2 in SNSCC tissue was 71.4%, which was significantly higher than that of normal inferior turbinate mucosa (25% (P0.01)). The expression of Survivin was positively correlated with the expression of Bcl-2 (P0.01). The higher the level of the tumor, the lower the expression level of Survivin and Bcl-2. Conclusion: Survivin and Bcl-2 are related to the occurrence and development of SNSCC, and Survivin may be the target of SNSCC gene therapy.
【作者单位】：汉中市中心医院耳鼻咽喉头颈外科;汉中市中心医院病理科;
【分类号】：R739.62
【正文快照】： synthase(iNOS)[J].Clin Epigenetics,2012,4:3-3.[16]KWON N H,KIM J S,LEE J Y,et al.DNA methyl-ation and the expression of IL-4and IFN-gamma pro-moter genes in patients with bronchial asthma[J].JClin Immunol,2008,28:139-146.[17]SOFER T,BACCARELLI A,CANTONE

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