手术干预对OSAHS合并代谢综合征患者血压、血脂及多种激素水平的影响

发布时间：2017-12-31 02:29

本文关键词：手术干预对OSAHS合并代谢综合征患者血压、血脂及多种激素水平的影响　出处：《宁夏医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的探究手术干预对阻塞性睡眠呼吸暂停低通气综合征(OSAH)合并代谢综合征(MS)患者血压、血脂及多种激素水平的影响情况,为患者的治疗提供临床理论依据。方法选取2013年1月至2014年10月于宁夏医科大学总医院心脑血管病医院接受治疗的OSAHS合并代谢综合征患者35例,观察手术治疗前后患者血压、血脂、血糖、胰岛素抵抗、甲状腺功能、生长激素及性激素水平情况,并将观察组分为轻、中、重三组,分别比较治疗前后三组患者的生理指标以及睡眠质量和生活质量情况。结果治疗后,患者的体重指数、收缩压、舒张压、腹围和颈围均小于治疗前,差异有统计学意义(P0.05);除高密度脂蛋白胆固醇外,治疗后空腹血糖、血浆胰岛素、胰岛素抵抗、尿酸、甘油三酯、低密度脂蛋白、总胆固醇各项生化指标均低于治疗前,差异有统计学意义(P0.05);尚不能认为三碘甲状腺原氨酸、甲状腺素、促甲状腺激素、生长激素手术前后有差异(P0.05)。手术治疗后睾酮水平大于治疗前,差异有统计学意义(P0.05);手术治疗后患者呼吸紊乱指数(AHI)低于治疗前,差异有统计学意义(P0.05);经过手术治疗后,观察组(ESS)评分,以及日、夜间主观症状的评分均低于治疗前,(P0.05);轻度、中度及重度患者的生活质量评分比较差异有统计学意义(P0.05)。结论应用手术干预,能够显著改善OSAHS合并MS患者体重、血压、血糖和性激素等指标,有效提高患者的睡眠质量,改善患者的生活质量,值得推广应用。
[Abstract]:Objective to explore the surgical intervention on obstructive sleep apnea hypopnea syndrome (OSAH) patients with metabolic syndrome (MS) patients with blood pressure, blood lipid and effect of several kinds of hormones, to provide theoretical basis for clinical treatment. Methods from January 2013 to October 2014 in the General Hospital of Ningxia Medical University of cardiovascular and cerebrovascular disease treated by OSAHS 35 cases with metabolic syndrome were observed before and after surgery in the patients' blood pressure, blood lipid, blood glucose, insulin resistance, thyroid function, hormone and sex hormone levels of growth, and the observation group divided into light, heavy, three groups were compared before and after treatment of physiological indexes of the three groups of patients and the quality of sleep and quality of life. Results after treatment, the patient's body mass index, systolic blood pressure, diastolic blood pressure, waist and neck are less than before treatment, the difference was statistically significant (P0.05); in addition to high density lipoprotein cholesterol After treatment, fasting blood glucose, plasma insulin, insulin resistance, uric acid, triglyceride, low density lipoprotein cholesterol, total biochemical indexes were lower than those before treatment, the difference was statistically significant (P0.05); it is not considered three triiodothyronine, thyroxine, thyroid stimulating hormone, growth hormone before and after surgery there are differences (P0.05). Testosterone levels than treatment after surgical treatment before, the difference was statistically significant (P0.05); patients with respiratory disturbance index after surgery (AHI) lower than that before treatment, the difference was statistically significant (P0.05); after surgical treatment, the observation group (ESS) score, and on the night, subjective symptom scores were lower than the treatment before (P0.05); mild, significant quality of life score in patients with moderate and severe differences (P0.05). Conclusion the application of surgical intervention can significantly improve patients with OSAHS MS body weight, blood pressure, blood glucose and hormone etc. Index, effectively improve the quality of the patients' sleep and improve the quality of life of the patients, it is worth popularizing.

【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R766;R589

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