三维扫描技术评估瑞蓝、美瑞两种透明质酸填充鼻唇沟效果

发布时间：2018-01-03 01:30

本文关键词：三维扫描技术评估瑞蓝、美瑞两种透明质酸填充鼻唇沟效果　出处：《东南大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：通过面部三维扫描技术对瑞蓝、美瑞两种透明质酸矫正鼻唇沟皱褶效果进行量化评估,以观察、比较两种透明质酸的作用特点与效果差异。方法：本研究通过对随机分成两组,美瑞组两组,各组15人,共30例(28例女性,2例男性)鼻唇沟评分在3分、4分的患者,分别使用瑞蓝、美瑞透明质酸进行鼻唇沟的注射填充,用V-TOP三维扫描仪采集其术前及术后20分钟、一周、一月、三月、六月的三维数据,并将鼻唇沟注射前的三维数据作为参考基线,采用Geomagic Qualify 13.0软件测量比较患者鼻唇沟注射前后的三维数据,量化评估鼻唇沟注射后变化,总结规律,比较不同种透明质酸的效果差异。结果：1.对透明质酸注射术后进行并发症及不良反应的统计,30例受试者25名术后局部无明显异常；3名患者稍有肿胀、疼痛,一周内自行好转；2例患者局部出现了瘀青,嘱局部进行热敷后一周左右消退。所有受试者均未出现变态过敏反应、迟发性过敏反应等严重的过敏反应。2、GAIS评分结果示：瑞蓝透明质酸,术后20分钟、一周、一月、三月、六月随访的改善率(除去恶化、无效的受试者),分别为100%、93.3%、83.3%、90%、80%。美瑞组结果分别为100%、100%、93.3%、83.3%、76.7%。表明两种透明质酸均有良好、持久的填充效果。3、利用面部三维扫描技术计算出,瑞蓝组透明质酸显效系数的平均数：术后20分钟、一周、一月、三月、六月分别为：0.678、0.729、0.578、0.542、0.466。美瑞透明质酸各时间点显效系数均值分别为：0.486、0.619、0.695、0.519、0.470。统计分析后得出各组随访时间对于显效系数有明显影响,且各时间点显效系数不全相同。4、瑞蓝透明质酸显效系数峰值出现在注射后一周,美瑞透明质酸显效系数峰值出现在填充后一月。结论：1、瑞蓝、美瑞两种透明质酸注射填充矫正鼻唇沟皱褶具有很好的效果,且安全可靠。两种透明质酸填充效果均随时间变化,且两种透明质酸长期填充效果无明显差异。2、本研究利用面部三维扫描技术,提供了一种面部测量评估的新方法,具有临床针对性,简便高效。
[Abstract]:Objective: to evaluate quantitatively the effect of two kinds of hyaluronic acid in correction of nasolabial crease by facial 3D scanning. Methods: this study was divided into two groups randomly, the two groups, 15 people in each group, a total of 30 cases of 28 women. Patients with nasolabial sulcus score of 3 and 4 were injected and filled with Raylan and Meridian, respectively. The patients were collected 20 minutes before and 20 minutes after operation by V-TOP 3D scanner. A week, January, March, June 3D data, and the nasolabial groove before injection of 3D data as a reference baseline. Geomagic Qualify 13.0 software was used to measure and compare the three dimensional data before and after nasolabial sulcus injection, to quantitatively evaluate the changes of nasolabial sulcus injection and to summarize the rule. Results: 1. Statistics of complications and adverse reactions after hyaluronic acid injection were performed in 30 subjects. There was no obvious local abnormality in 25 subjects after hyaluronic acid injection. Three patients had slight swelling and pain, and recovered within a week. Two patients suffered from local bruise, and were told to apply hot compress for a week or so. All the subjects had no abnormal allergic reaction, delayed allergic reaction and other serious allergic reactions. 2. GAIS score showed that the improvement rate of hyaluronic acid 20 minutes, one week, January, March and June was 93.3% respectively. The results of the Meirui group were 100 and 93.3, respectively, indicating that both kinds of hyaluronic acid were good. Lasting filling effect. 3. The mean value of hyaluronic acid apparent coefficient in the Raylan group was calculated by 3D facial scanning technique: 20 minutes, one week, January, March, June, respectively. The average apparent effect coefficient of Meridian at different time points was 0: 0. 486 / 0. 619 / 0. 695 ~ 0. 519 respectively. 0.470. After statistical analysis, it was concluded that the follow-up time of each group had a significant effect on the apparent effect coefficient, and the apparent effect coefficient was not all the same at each time point. The peak value of the apparent effect coefficient of Ruilan hyaluronic acid appeared one week after injection. The peak value of hyaluronic acid effective coefficient appeared on January after filling. Conclusion injection filling with two kinds of hyaluronic acid to cure nasolabial crease is effective. The filling effect of two kinds of hyaluronic acid varies with time, and the long-term filling effect of two kinds of hyaluronic acid has no obvious difference. A new method for evaluation of facial measurement is provided, which has clinical pertinence and is simple and efficient.
【学位授予单位】：东南大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R622;R765.9

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