丝裂霉素联合复合式小梁切除术治疗难治性青光眼疗效

发布时间：2018-01-05 10:22

本文关键词：丝裂霉素联合复合式小梁切除术治疗难治性青光眼疗效　出处：《国际眼科杂志》2016年03期 　论文类型：期刊论文

【摘要】：目的:探讨丝裂霉素联合复合式小梁切除术在难治性青光眼患者中的效果。方法:选取我院2014-01/2015-06收治的难治性青光眼患者110例122眼,采用随机数字表法分为观察组55例62眼和对照组55例60眼,均行复合式小梁切除手术治疗,观察组患者术中加用丝裂霉素C。术后随访12mo,对患者眼压及视力进行测量,术前及术后3mo清晨采集空腹血3 m L,ELISA法其血清维生素B12(VB12)、维生素B6(VB6)、叶酸(FA)及白介素-2(IL-2),白介素-6(IL-6)水平。结果:术前,两组眼压比较无显著性差异(P0.05),术后1wk~12mo,观察组眼压均显著低于对照组(P0.01);术前,两组视力比较无显著性差异(P0.05),术后1wk~12mo,观察组视力均显著高于对照组(P0.01);术前,两组患者VB12、VB6、FA、IL-2、IL-6比较均无显著性差异(P0.05),术后3mo,观察组VB12、FA、IL-2、IL-6均显著高于对照组(P0.05)。结论:丝裂霉素C联合复合式小梁切除术治疗难治性青光眼可有效控制眼压、提高视力,改善病情,提高难治性青光眼的治疗成功率。
[Abstract]:Objective: to investigate the effect of mitomycin combined with trabeculectomy in patients with refractory glaucoma. One hundred and ten patients (122 eyes) with refractory glaucoma who were admitted to our hospital in 2014-01 / 2015-06 were selected. The patients in the observation group were randomly divided into two groups: the observation group (55 cases, 62 eyes) and the control group (55 cases, 60 eyes). The patients in the observation group were treated with combined trabeculectomy. The patients in the observation group received mitomycin C during the operation and were followed up for 12 months. Intraocular pressure (IOP) and visual acuity were measured. Serum vitamin B12 (VB12) and vitamin B6 (VB6) were collected before and 3 months after operation. Results: there was no significant difference in intraocular pressure between the two groups before operation (P 0.05). The intraocular pressure in the observation group was significantly lower than that in the control group (P 0.01). Before operation, there was no significant difference in visual acuity between the two groups (P 0.05). The visual acuity of the observation group was significantly higher than that of the control group (P 0.01). Before operation, there was no significant difference between the two groups in VB12, VB6 and IL-2IL-6, but there was no significant difference between the two groups at 3 moths after operation, the observation group had VB12FAA IL-2. Conclusion: mitomycin C combined with combined trabeculectomy can effectively control IOP, improve visual acuity and improve the condition of refractory glaucoma. To improve the success rate of treatment of refractory glaucoma.
【作者单位】：中国湖北省恩施州中心医院眼科;
【分类号】：R779.6
【正文快照】： 0引言青光眼是一种临床常见致盲眼病,主要以视野缺损的进行性加重和视神经萎缩为特征[1]。近年来,我国青光眼的发病率逐渐升高,严重威胁着人们健康。临床上青光眼主要通过手术方式控制患者眼压,但其视功能损害仍在继续,患者最终因视神经萎缩,视功能完全丧失而致失明[2-3]。难

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