复方双花片联合西药对急性分泌性中耳炎患者血清及分泌物炎症因子的影响

发布时间：2018-01-06 08:22

本文关键词：复方双花片联合西药对急性分泌性中耳炎患者血清及分泌物炎症因子的影响　出处：《中国生化药物杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨复方双花片联合西药对急性分泌性中耳炎(secretory otitis media,SOM)患者血清及分泌物肿瘤坏死因子(tumor necrosis factor,TNF-α)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-10(interleukin-10,IL-10)的影响。方法选择2014年8月~2016年6月浙江新昌人民医院收治的200例(244耳)SOM患者随机分为2组,对照组100例(120耳)仅予常规西医治疗,治疗组100例(124耳)在对照组基础上联合复方双花片治疗,治疗前后分别采集患者外周静脉血及中耳积液利用流式细胞术微球阵列法对TNF-α、IL-6及IL-10进行检测,对比2组疗效。结果治疗组的总有效率为97.58%高于对照组的85.00%,差异有统计学意义(P0.05)。2组治疗前后血清TNF-α、IL-6、IL-10水平无明显变化,差异无统计学意义。2组治疗后分泌物TNF-α、IL-6、IL-10水平明显降低,且治疗组明显低于对照组,差异有统计学意义(P0.05)。结论复方双花片联合西药治疗SOM的疗效显著,可有效减少中耳积液中的TNF-α、IL-6、IL-10等炎症因子。
[Abstract]:Objective to study the effect of compound Shuanghua tablets combined with western medicine on secretory otitis media in acute secretory otitis media. Serum and secretion tumor necrosis factor-TNF- 伪 and interleukin-6. IL-6, IL-10, interleukin-10. Methods from August 2014 to June 2016, 200 patients with Soma in Xinchang people's Hospital of Zhejiang Province were randomly divided into two groups. The control group (100 cases, 120 ears) was treated with routine western medicine only, the treatment group (100 cases, 124 ears) was treated with compound Shuanghua tablet on the basis of the control group. Peripheral venous blood and middle ear effusion were collected before and after treatment. TNF- 伪 IL-6 and IL-10 were detected by flow cytometry microsphere array. Results the total effective rate of the treatment group was 97.58% higher than that of the control group (85.00). The difference was statistically significant before and after treatment. The level of IL-10 in IL-6 was not significantly changed, and the level of IL-10 in secretion of group 2 was significantly lower than that in control group after treatment, and the level of IL-10 in the treatment group was significantly lower than that in the control group. Conclusion compound Shuanghua tablet combined with western medicine is effective in the treatment of SOM and can effectively reduce TNF- 伪 IL-6 in middle ear effusion. IL-10 and other inflammatory factors.
【作者单位】：浙江新昌人民医院耳鼻喉科;
【分类号】：R764.21
【正文快照】： 急性分泌性中耳炎(secretory otitis media,SOM)是以中耳积液为主要特征的中耳非化脓性炎性疾病,临床表现主要为耳闷塞感、耳痛及听力下降等,为临床常见耳部疾病。研究显示,感染、咽鼓管功能异常及自身免疫反应是引发SOM发病的主要原因,且在“上下呼吸道炎症一致性”概念得到

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