术前化疗对眼内期视网膜母细胞瘤术后病理及预后的影响

发布时间：2018-01-06 23:22

  本文关键词：术前化疗对眼内期视网膜母细胞瘤术后病理及预后的影响　出处：《中国小儿血液与肿瘤杂志》2016年05期 　论文类型：期刊论文

  更多相关文章： 视网膜母细胞瘤 术前化疗 病理分级 生存率

【摘要】：目的探讨术前全身化疗对眼内期视网膜母细胞瘤(RB)术后眼球病理分级及生存率的影响。方法选取北京同仁医院儿科2008年1月-2009年12月术前临床诊断同时经眼球摘除后病理确诊的为D期及E期的223例RB患儿为研究对象。根据其病理分级标准肿瘤侵犯视神经的程度分为5级:0级为未侵犯视神经;1级为侵犯视乳头;2级为侵犯筛板;3级为侵犯筛板之后,未到视神经断端;4级为侵犯视神经断端。分别将D、E期患儿根据术前化疗与否分为2组:第一组术前未行化疗组;第二组术前化疗组(1~6个周期)。分析两组眼病理视神经侵犯程度及预后。结果 223例患儿共263只眼,其中D期68只眼,E期患儿155只眼,双眼中对侧眼A期28只眼,B期12只眼;双眼患儿40例,单眼183例;男148例,女95例;发病平均年龄24.4±17.0个月,中位发病年龄21个月。D期及E期患儿术前未行化疗组与化疗组眼病理视神经侵犯程度差异均具有显著性;D期患儿术前未行化疗组与化疗组眼病理肿瘤细胞穿过筛板发生率差异无显著性(P0.05),而E期术前未行化疗组与化疗组眼病理肿瘤细胞穿过筛板发生率差异具有显著性(P0.05)。术后5年生存率D期为98.5%,E期为96.1%。D期及E期术前化疗组与未化疗组之间生存率差异无显著性(P0.05)。结论术前全身化疗是眼内期分期D、E期RB的术后病理分级的影响因素。对D、E期RB患儿术前行化疗与否并不影响患儿的总生存率。
[Abstract]:Objective to explore the effect of preoperative chemotherapy on intraocular intraocular retinoblastoma (RB) postoperative eyeball pathological grading and survival. Methods from January 2008 -2009 December Beijing Tongren Hospital pediatric preoperative clinical diagnosis and pathology diagnosis by enucleation in 223 cases of children with RB D and E as the research object. According to the histological grading tumor invasion of the optic nerve was divided into 5 grades: grade 0 is not involving the optic nerve; the 1 level for the invasion of optic papilla; the 2 level for the invasion of sieve plate; the 3 level for the invasion of plate after not to the optic nerve stump; the 4 level for the invasion of optic nerve stump. Respectively, D, E according to preoperative chemotherapy were divided into 2 groups: the first group received chemotherapy before surgery; second groups preoperative chemotherapy group (1~6 cycles). Analysis of two groups of eye and the degree of optic nerve invasion and prognosis. Results 223 patients 263 eyes, including 68 eyes of stage D, stage E in 155 eyes in my eyes, 瀵逛晶鐪糀鏈，

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