不同方法治疗全视网膜光凝后黄斑水肿的疗效比较

发布时间：2018-01-08 14:35

本文关键词：不同方法治疗全视网膜光凝后黄斑水肿的疗效比较　出处：《国际眼科杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的:研究玻璃体腔注射曲安奈德(TA)与口服羟苯磺酸钙在治疗全视网膜激光光凝引起的黄斑水肿方面的疗效及安全性的差异。方法:前瞻性研究。分析2012-01/2015-01在我院眼科治疗的全视网膜激光光凝后继发黄斑水肿患者72例72眼的临床资料。所有患者均因患有严重的糖尿病视网膜病变而行全视网膜激光光凝治疗,治疗后出现不同程度的视网膜黄斑区水肿,或原有黄斑水肿加重。按照随机原则分为2组:行玻璃体腔注射TA(0.025mL,1mg),简称注射组36眼;口服羟苯磺酸钙胶囊,简称口服组36眼。观察两组治疗前,治疗后1、3、6mo的最佳矫正视力(best corrected visual acuity,BCVA)、黄斑中心凹厚度(central macular thickness,CMT)、眼压(intraocular pressure,IOP)及并发症情况。结果:两组患者的基线特征相比,差异无统计学意义(P0.05)。注射组治疗后1、3、6mo BCVA、CMT均明显改善,与治疗前相比,差异均有统计学意义(均P0.05);眼压无明显变化,与治疗前相比,差异均无统计学意义(均P0.05)。口服组治疗后1、3、6mo BCVA、CMT均无明显改善,与治疗前相比,差异均无统计学意义(均P0.05);眼压无明显变化,与治疗前相比,差异均无统计学意义(均P0.05)。治疗后1、3、6mo,注射组的BCVA、CMT均明显优于同时间段口服组的BCVA、CMT,差异均有统计学意义(均P0.05);而两组治疗后同时间段的眼压相比,差异均无统计学意义(均P0.05)。两组治疗后均未见严重的眼部及全身并发症。结论:玻璃体腔注射1mg的TA在改善全视网膜激光光凝后继发黄斑水肿患者的BCVA、CMT方面明显优于口服羟苯磺酸钙,两种药物治疗后均未引发明显的副作用及严重并发症,治疗安全性较好。
[Abstract]:Objective: To study the effect of intravitreal injection of Cu Ann Ned (TA) and oral calcium dobesilate in treatment of laser photocoagulation of the efficacy and safety of macular edema the difference. Methods: a prospective study. Analysis of retinal bowel 2012-01/2015-01 in our hospital ophthalmology treatment light after photocoagulation in patients with macular edema in 72 cases 72 the eyes of the clinical data. All patients were suffering from severe diabetic retinopathy underwent laser photocoagulation treatment, different degrees of retinal macular edema after the treatment, or the original macular edema aggravated. They were randomly divided into 2 groups: Intravitreal injection of TA (0.025mL, 1mg), referred to as the injection group, 36 eyes oral; Calcium Dobesilate Capsules, referred to as the oral group 36 eyes. Two groups were observed before treatment, the best corrected visual acuity of 1,3,6mo after treatment (best corrected visual acuity, BCVA), foveal thickness (central macu Lar thickness, CMT), intraocular pressure (intraocular pressure, IOP) and complications. Results: the baseline characteristics of the two groups were compared, the difference was not statistically significant (P0.05). After the treatment of 1,3,6mo BCVA injection group, CMT were significantly improved, compared with before treatment, the differences were statistically significant (P0.05); intraocular pressure no significant changes compared with before treatment, there were no significant differences (P0.05). Oral treatment group after 1,3,6mo BCVA and CMT were not significantly improved, compared with before treatment, there were no significant differences (P0.05); intraocular pressure had no obvious change, compared with before treatment, there were no significant differences (all P0.05). After treatment 1,3,6mo, BCVA injection group, CMT was significantly higher than that in the same period of oral groups BCVA and CMT, the differences were statistically significant (P0.05); and the two group after treatment, intraocular pressure in the same period, there were no significant differences (P0.05). The two groups after treatment were not found Ocular and systemic complications. Conclusion: Intravitreal injection of 1mg TA in the improvement of laser photocoagulation in patients with macular edema secondary to BCVA, CMT is superior to oral calcium dobesilate, after the treatment of the two drugs were not cause significant side effects and severe complications, treatment with good safety.

【作者单位】：中国河南省濮阳市人民医院眼科;新乡医学院药学院;
【分类号】：R779.63
【正文快照】： 妁METHODS:A study was performed on the clinicalm aterial of 72 patients(72 eyes in total)w ith m acularedem a due to panretinal photocoagulation under thetreatm ent in our hospital from Jan.2012 to Jan.2015.Allof the 72 eyes w ere underw ent treatm ent w

【相似文献】