CPAP对阻塞性睡眠呼吸暂停低通气综合征患者血管内皮功能影响

发布时间：2018-01-12 04:37

本文关键词：CPAP对阻塞性睡眠呼吸暂停低通气综合征患者血管内皮功能影响　出处：《世界最新医学信息文摘》2016年83期 　论文类型：期刊论文

【摘要】：目的研究持续气道正压通气(CPAP)对OSAHS患者的临床疗效。方法将99例经整夜多导睡眠监测确诊为阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者,根据呼吸暂停低通气指数(AHI)将患者分为三组:轻度、中度、重度,持续气道正压通气(CPAP)治疗前、后分别测量血浆中的NO、CGRP、ET、MCP-1和抵抗素的水平。另取门诊健康查体者20例作为(正常)对照组,对比分析研究。结果治疗前,三组不同水平阻塞性睡眠呼吸暂停低通气综合征患者NO、CGRP、ET、MCP-1及抵抗素水平与对照组比较,差别有统计学意义(P0.05)。CPAP治疗后,三组不同水平的阻塞性睡眠呼吸暂停低通气综合征患者血浆中NO、CGRP、ET、MCP-1和抵抗素水平较治疗前均明显改善,且以中、重度OSAHS改善更加明显,组间及组内比较差异有统计学意义(P0.05)。结论持续气道正压通气治疗能明显改善阻塞性睡眠呼吸暂停低通气综合征患者血浆中NO、CGRP、ET、MCP-1和抵抗素水平的代谢失衡,起到调节内皮细胞功能稳定作用。
[Abstract]:Objective to study the continuous positive airway pressure (CPAP) on the clinical curative effect of OSAHS patients. Methods 99 cases were diagnosed by whole night polysomnography of obstructive sleep apnea hypopnea syndrome (OSAHS) patients, according to apnea hypopnea index (AHI) were divided into three groups: mild, moderate and severe, continuous positive airway pressure (CPAP) were measured before treatment, plasma NO, CGRP, ET, MCP-1 and resistin levels. Another clinic of 20 healthy persons as control group (normal), the study of comparative analysis. Results before treatment, three groups of different levels of obstructive sleep apnea in patients with NO, ET, CGRP hypopnea syndrome, group MCP-1 and resistin level with the control, the difference was statistically significant (P0.05) after.CPAP treatment, three groups of different levels in obstructive sleep apnea hypopnea syndrome patients with plasma NO, CGRP, ET, MCP-1 and resistin treatment Before treatment were significantly improved, and in severe OSAHS, the improvement is more obvious, between group and within group differences were statistically significant (P0.05). Conclusion CPAP treatment can significantly improve obstructive sleep apnea hypopnea syndrome patients with plasma NO, CGRP, ET, MCP-1 and resistin levels in metabolic imbalance, to adjust the function of endothelial cell stability.

【作者单位】：石家庄市第二医院检验科;
【分类号】：R766
【正文快照】： 血管内皮细胞的活化和损伤与器官功能障碍密切相关。目前有研究证明[1-2],阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome OSAHS)患者体内微炎症相关的内皮细胞损伤被认为是病情加重,靶器官损害的机制之一。那么,对于阻塞性睡眠呼吸暂停低通气综

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