单点多次和多点一次性完成视网膜激光光凝对非增生期糖尿病视网膜病变的临床疗效对比观察

发布时间：2018-01-17 00:20

本文关键词：单点多次和多点一次性完成视网膜激光光凝对非增生期糖尿病视网膜病变的临床疗效对比观察　出处：《临床和实验医学杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的探讨单点多次和多点一次性完成视网膜激光光凝对非增生期糖尿病视网膜病变的临床疗效。方法将2011年6月至2014年6月医院收治的86例(102只眼)非增生期DR患者按照随机数字表法分为研究组43例(53只眼)和对照组43例(49只眼),研究组采用多点扫描模式一次性完成视网膜激光光凝,对照组采用单点扫描模式分3~5次完成视网膜激光光凝;比较两组患者激光能量、光斑数、激光能量密度,分别于治疗前、治疗后1、3、6个月检测两组患者视野阈值敏感度、全视野闪光视网膜电图a、b波振幅及黄斑中心凹厚度。结果研究组激光能量显著高于对照组,光斑数、激光能量密度显著低于对照组,两组间比较差异具有统计学意义(P0.05);研究组和对照组最佳矫正视(BCVA)显著提高(P0.05),两组间BCVA比较差异无统计学意义(P0.05);两组治疗前后及组间黄斑中心凹厚度(CMT)比较差异均无统计学意义(P0.05)。治疗后两组患者全视野闪光视网膜电图(F-ERG)a、b波振幅、视野阈值敏感度先呈降低趋势,然后逐渐上升,其中治疗1个月、3个月两组患者F-ERG a、b波振幅、视野阈值敏感均显著低于治疗前组(P0.05);两组间治疗前后各时段F-ERG a、b波振幅、视野阈值敏感比较差异均无统计学意义(P0.05)。两组患者治疗后6个月随访期间均未出现明显灌注区及新生血管等严重不良反应。结论单点多次和多点一次性完成视网膜激光光凝治疗非增生期DR对患者视力改善情况相当,而多点一次完成视网膜激光光凝能够显著降低能量密度,最大程度降低因激光治疗对视网膜造成的损伤。
[Abstract]:Objective to investigate the clinical effect of single point multiple and multipoint laser photocoagulation in the treatment of non-proliferative diabetic retinopathy. Methods 86 cases of non-proliferative diabetic retinopathy were treated in our hospital from June 2011 to June 2014. 102 eyes) Non-proliferative Dr patients were randomly divided into study group (43 cases, 53 eyes) and control group (43 cases, 49 eyes). In the study group, the retinal laser photocoagulation was performed in a single point scanning mode, while in the control group, the retinal laser photocoagulation was completed in 3 to 5 times. Laser energy, spot number and laser energy density were compared between the two groups. The visual field threshold sensitivity and full field flash electroretinogram a were measured before treatment, 1 month after treatment and 6 months after treatment. Results the laser energy in the study group was significantly higher than that in the control group, and the number of spot and laser energy density in the study group were significantly lower than those in the control group. The difference between the two groups was statistically significant (P 0.05). The optimal corrected visual acuity (BCVA) in the study group and the control group was significantly higher than that in the control group (P 0.05). There was no significant difference in BCVA between the two groups. There was no significant difference in macular foveal thickness and CMT between the two groups before and after treatment (P 0.05). The amplitude of B wave and the sensitivity of visual field threshold were decreased firstly and then increased gradually. The amplitude of F-ERG afib wave in two groups were treated for 1 month and 3 months. The sensitivity of visual field threshold was significantly lower than that of pre-treatment group (P 0.05). The amplitude of F-ERG afib wave before and after treatment between the two groups. There was no significant difference in visual field threshold sensitivity (P0.05). There were no significant adverse reactions such as perfusion area and neovascularization during the follow-up of 6 months after treatment in both groups. Conclusion the retinal laser photocoagulation for non-proliferative phase Dr was performed at one point and multiple points at one time. The improvement is comparable. Multipoint laser photocoagulation can significantly reduce the energy density and minimize the retinal damage caused by laser therapy.
【作者单位】：首都医科大学燕京医学院附属密云医院眼科;
【分类号】：R587.2;R774.1
【正文快照】： 分3~5次完成视网膜激光光凝;比较两组患者激光能量、光斑数、激光能量密度,分别于治疗前、治疗后1、3、6个月检测两组患者视野阈值敏感度、全视野闪光视网膜电图a、b波振幅及黄斑中心凹厚度。结果研究组激光能量显著高于对照组,光斑数、激光能量密度显著低于对照组,两组间比较

【相似文献】