化脓性角膜炎患者病原菌与耐药性分析

发布时间：2018-01-17 19:17

本文关键词：化脓性角膜炎患者病原菌与耐药性分析　出处：《中华医院感染学杂志》2017年15期 　论文类型：期刊论文

【摘要】：目的探讨化脓性角膜炎患者的病原菌与耐药性,为临床治疗提供参考依据。方法选择医院2008年1月-2015年12月化脓性角膜炎患者292例(共300眼)作为研究对象,收集患者的临床资料、病原学检查结果及药物敏感实验结果。结果 292例化脓性角膜炎病因中,眼外伤118例占40.4%,配戴角膜接触镜21例占7.2%,眼部原有疾病28例占9.6%,全身性疾病29例占9.9%,眼部手术史9例占3.1%;246只眼进行了病原学检查,108只眼检出有病原菌,病原菌检出率为43.9%,12眼为真菌和细菌混合感染,96眼为单一致病菌感染,85只真菌性角膜炎眼中检出真菌37眼,检出率为43.5%,203例细菌性角膜炎眼中检出细菌59眼,检出率为29.1%;共检出108株病原菌,以革兰阳性菌为主,共40株占37.0%;表皮葡萄球菌对哌拉西林耐药率为91.3%,对红霉素的耐药率为82.6%;溶血性链球菌对氨苄西林的耐药率为83.3%,对红霉素的耐药率为66.7%,绿脓杆菌对红霉素的耐药率为100.0%,对氨苄西林的耐药率为86.4%。结论化脓性角膜炎的病原菌主要为表皮葡萄球菌和绿脓杆菌,两者的耐药性比较显著。
[Abstract]:Objective to investigate the pathogenic bacteria and drug resistance in patients with suppurative keratitis. Methods 292 cases (300 eyes) of suppurative keratitis from January 2008 to December 2015 in hospital were selected as the study object and the clinical data were collected. Results of 292 cases of suppurative keratitis, 118 cases were ocular trauma and 21 cases were wearing contact lens. There were 28 cases with ocular diseases, 29 cases with systemic diseases, 9 cases with ocular diseases, and 9 cases with ocular surgery history. Pathogenic bacteria were detected in 108 eyes of 246 eyes. The detection rate of pathogenic bacteria was 43.9%, 12 eyes were mixed infection of fungi and bacteria, 96 eyes were single pathogenic bacteria. There were 37 eyes of fungi in 85 eyes of fungal keratitis and 59 eyes of bacteria were detected in 203 cases of bacterial keratitis, the detectable rate was 29.1%. A total of 108 strains of pathogenic bacteria were detected, mainly Gram-positive bacteria, a total of 40 strains (37.0%); The resistance rate of Staphylococcus epidermidis to piperacillin and erythromycin was 91.3 and 82.6 respectively. The resistance rate of Streptococcus haemolyticus to ampicillin was 83.3%, to erythromycin was 66.7%, and that of Pseudomonas aeruginosa to erythromycin was 100.0%. Conclusion Staphylococcus epidermidis and Pseudomonas aeruginosa are the main pathogens of suppurative keratitis.
【作者单位】：宁波市鄞州区第二医院眼科;
【基金】：浙江省医药卫生基金资助项目(2016KYA160)
【分类号】：R772.21
【正文快照】： 化脓性角膜炎是眼科常见的感染性疾病,伴有或不伴有脓性分泌物,是我国主要的致盲性眼病,对患者的视功能造成严重威胁,化脓性角膜炎的主要病原菌为细菌和真菌,化脓性角膜炎病情危重、疾病急,如果治疗不恰当或者诊治不及时,可引起眼内炎、眼内容物脱出、角膜穿孔等严重并发症,即

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