RhoA、Ezrin和CD44在喉鳞状细胞癌组织中的表达及临床意义

发布时间：2018-01-18 12:16

本文关键词：RhoA、Ezrin和CD44在喉鳞状细胞癌组织中的表达及临床意义　出处：《临床耳鼻咽喉头颈外科杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的:检测RhoA、Ezrin和CD44蛋白在喉鳞状细胞癌(LSCC)组织中的表达,探讨三者在LSCC浸润转移中的作用及其相关性。方法:应用免疫组织化学SABC法检测68例LSCC组织及35例喉正常鳞状上皮组织中RhoA、Ezrin和CD44蛋白的表达水平,并结合临床病理特征进行统计学分析。结果:RhoA、Ezrin和CD44蛋白在LSCC组织的阳性表达率分别为80.9%、82.4%和70.6%,在喉正常鳞状上皮组织中的阳性表达率分别为28.5%、25.7%和20.0%。2组间的3种蛋白表达比较差异均有统计学意义(P0.05)。RhoA、Ezrin和CD44表达水平与LSCC患者的年龄、性别、吸烟与否、肿瘤部位无关(P0.05),而与肿瘤的分化程度、浸润程度、淋巴结的转移、TNM分期密切相关(P0.05)。LSCC组织中RhoA、Ezrin和CD44蛋白表达呈正相关。结论:RhoA、Ezrin和CD44蛋白在LSCC的浸润转移中均发挥重要作用,提示三者在该过程中起协同作用。
[Abstract]:Objective: to detect RhoA, Ezrin and CD44 protein in laryngeal squamous cell carcinoma (LSCC) expression in tissues, and to discuss the three LSCC in the infiltration effect and correlation metastasis. Methods: RhoA immunohistochemistry was applied to detect SABC in 68 cases of LSCC tissues and 35 cases of normal laryngeal squamous epithelium, the expression level of Ezrin and CD44 protein, and analyzed with clinical pathological characteristics. Results: the RhoA positive expression of Ezrin and CD44 protein in LSCC tissues were 80.9%, 82.4% and 70.6%, the positive expression in normal laryngeal squamous epithelium in 28.5% respectively, there were significant differences in the expression of 3 proteins and 25.7% 20.0%.2 groups the (P0.05).RhoA, Ezrin and CD44 expression level in patients with LSCC, age, gender, smoking status, tumor site (P0.05), degree of differentiation, and tumor infiltration, lymph node metastasis, closely related to the TNM staging (P0.05) The expression of RhoA, Ezrin and CD44 protein was positively correlated in.LSCC tissues. Conclusion: RhoA, Ezrin and CD44 proteins play an important role in the invasion and metastasis of LSCC, suggesting that the three play a synergistic role in this process.

【作者单位】：河北北方学院;河北北方学院附属第一医院耳鼻咽喉科;
【基金】：河北省卫生厅重大项目(No:20160351;ZL20140151;Q2012100)
【分类号】：R739.65
【正文快照】： 喉癌是头颈部常见肿瘤之一,在耳鼻喉科肿瘤中发病率仅次于鼻咽癌和鼻腔鼻窦癌,其中以喉鳞状细胞癌为主,约占喉癌的95%。近年来喉癌的发病率有上升趋势,由于喉癌早期可出现声嘶,如早诊断早治疗,可通过手术、放疗或其他治疗加以有效控制后,预后相对较好。但根据最新研究显示喉癌

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