IL-23和IL-17在OSAHS患者外周血中的水平变化及意义

发布时间：2018-01-19 21:28

本文关键词： 睡眠呼吸暂停低通气综合征 IL- IL-　出处：《安徽医科大学学报》2017年04期 　论文类型：期刊论文

【摘要】：探讨白介素(IL)-23和IL-17在睡眠呼吸暂停低通气综合征(OSAHS)患者外周血中的水平变化及临床意义。通过ELISA法检测OSAHS患者与正常健康者血清及外周血单个核细胞(PBMCs)上清液中IL-23、IL-17的水平,检测经韩氏悬雍垂腭咽成形术(H-UPPP)治疗前后OSAHS患者血清中IL-23、IL-17含量的变化。OSAHS患者血清及培养的PBMCs上清液中IL-23和IL-17的水平均高于对照组(P0.05),血清IL-23和IL-17水平随OSAHS严重程度增加而增高,血清和PBMCs上清液中IL-23与IL-17水平均呈正相关性(rs=0.644,P0.01;rs=0.251,P0.05)。经H-UPPP术2个月后,患者血清IL-23、IL-17水平和呼吸紊乱指数均较治疗前有明显降低(P0.05),患者睡眠质量和夜间低氧有明显改善,最低血氧饱和度较治疗前显著升高(P0.05)。IL-23和IL-17可能在OSAHS的发病及预后中发挥着重要作用。
[Abstract]:Study on Interleukin-23 and IL-17 in patients with Sleep Apnea hypopnea Syndrome (OSAHS). The serum and peripheral blood mononuclear cells (PBMC) supernatant of patients with OSAHS and normal controls were detected by ELISA method. The levels of IL-17 in serum of patients with OSAHS before and after treatment with Ham's uvulopalatopharyngoplasty were detected. Changes of IL-17 content. The levels of IL-23 and IL-17 in serum and PBMCs supernatant of OSAHS patients were higher than those of control group (P0.05). Serum IL-23 and IL-17 levels increased with the severity of OSAHS. There was a positive correlation between IL-23 and IL-17 in serum and PBMCs supernatant. After 2 months of H-UPPP, serum IL-23 was obtained. The levels of IL-17 and respiratory disturbance index were significantly lower than those before treatment, and the sleep quality and nocturnal hypoxia were significantly improved. The lowest oxygen saturation was significantly higher than that before treatment. IL-23 and IL-17 may play an important role in the pathogenesis and prognosis of OSAHS.
【作者单位】：桂林医学院附属医院耳鼻喉头颈外科;
【基金】：广西壮族自治区卫生厅科技研究计划课题(编号:Z2007221)
【分类号】：R766
【正文快照】： 2016-12-12接收阻塞性睡眠呼吸暂停低通气综合征(obstructivesleep apnea-hypopnea syndrome,OSAHS)是指睡眠中出现的上气道反复塌陷阻塞,伴睡眠紊乱、呼吸暂停、血氧降低、高碳酸血症、白天嗜睡、打鼾等症状,可导致心血管疾病[1]等并发症,严重危害人们的健康。目前,OSAHS的发

【相似文献】