阻塞性睡眠呼吸暂停低通气综合征患者血清S100A12水平的研究

发布时间：2018-01-21 13:09

  本文关键词： 睡眠呼吸暂停 阻塞性 SA 相关性　出处：《重庆医学》2017年34期 　论文类型：期刊论文

【摘要】：目的探讨S100A12与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的相关性及意义。方法选择OSAHS患者53例为OSAHS组,选择体检的健康志愿者46例为对照组,比较两组血清S100A12及hs-CRP水平,并分别与epworth嗜睡评分(ESS)、呼吸暂停低通气指数(AHI)、最低血氧饱和度(L-SpO2)进行相关性分析。结果两组ESS评分、BMI、AHI、L-SpO2、hsCRP、S100A12比较差异均有统计学意义(P0.05);重度OSAHS组hs-CRP值明显高于轻度OSAHS组,差异有统计学意义(P0.05)。中度OSAHS组hs-CRP值与轻度组、重度组比较差异均无统计学意义(P0.05);重度组S100A12值明显高于中度组及轻度组,中度组S100A12高于轻度组,组间比较差异均有统计学意义(P0.01)。hs-CRP与ESS、AHI呈正相关(r=0.822、0.787,P0.01),与L-SpO2呈负相关(r=-0.740,P0.01);S100A12与ESS、AHI呈正相关(r=0.707、0.807,P0.01),与L-SpO2呈负相关(r=-0.670,P0.01)。结论 S100A12与OSAHS具有相关性,OSAHS越严重S100A12值越高,S100A12可作为新的预测OSAHS患者心血管疾病风险的指标。
[Abstract]:Objective to investigate the relationship between S100A12 and obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 53 patients with OSAHS were selected as OSAHS group. The serum levels of S100A12 and hs-CRP were compared with those of epworth sleepiness score (ESS) in 46 healthy volunteers as control group. The correlation analysis of apnea hypopnea index (AHI) and minimum oxygen saturation (L-SpO2) was carried out. Results the ESS score of the two groups was BMI-AHI L-SpO2hsCRP. The difference of S100A12 was statistically significant (P 0.05). The hs-CRP value of severe OSAHS group was significantly higher than that of mild OSAHS group (P 0.05). The hs-CRP value of moderate OSAHS group was significantly higher than that of mild OSAHS group. There was no significant difference between severe group and severe group (P 0.05). The value of S100A12 in severe group was significantly higher than that in moderate group and mild group, and S100A12 value in moderate group was higher than that in mild group. There was a positive correlation between P0.01hs-CRP and ESSAHI (P 0.01). There was a negative correlation between L-SPO _ 2 and L-SPO _ 2. S100A12 was positively correlated with ESSN AHI and negatively correlated with L-SPO _ 2. Conclusion there is a correlation between S100A12 and OSAHS. The more serious S100A12 is, the higher the S100A12 value is. S 100 A 12 can be used as a new predictor of cardiovascular disease risk in patients with OSAHS.
【作者单位】： 郑州大学附属郑州中心医院呼吸科;郑州大学第一附属医院呼吸科;郑州大学附属郑州中心医院心内科;
【基金】：郑州市科技攻关项目(20150055)
【分类号】：R766
【正文快照】： 3.郑州大学附属郑州中心医院心内科450000)阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep ap-nea-hypopnea syndrome,OSAHS)是一种全身性疾病,可诱发或加重高血压、冠状动脉粥样硬化性心脏病等,与心血管疾病密切相关[1]。钙结合蛋白S100A12是新发现的心血管疾病预测因子,，

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