加减黄芪防己汤在喉癌术后放疗引起的迟发性淋巴水肿中的应用

发布时间：2018-01-22 08:10

  本文关键词： 喉癌 黄芪防己汤 放疗 水肿　出处：《中国中西医结合杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的探讨加减黄芪防己汤在喉癌术后局部放疗引起的迟发性淋巴水肿治疗中的效果。方法将60例喉癌手术后放疗患者分为中药治疗组和对照组,每组30例,每组包括20例部分喉切除及10例全喉切除病例,对照组中有13例行颈淋巴结清扫,术后仅予常规调强放疗。中药治疗组有16例行颈淋巴结清扫,术后行调强放疗同时给予黄芪防己汤加减,每日1剂,分2次口服,中药疗程为10周。放疗结束1个月后,利用改良Miller和LENT-SOMA评分系统分别对各组放疗引起的喉及颈部的迟发性淋巴水肿进行评估,采用视觉量表(VAS)对患者的生活质量进行评估。结果与对照组比较,中药治疗组喉及颈部迟发性淋巴水肿的反应分级明显降低(P0.01,P0.05),VAS分值亦降低(P0.01)。结论加减黄芪防己汤能有效地预防和减轻放疗引起迟发性淋巴水肿反应。
[Abstract]:Objective to investigate the effect of Astragalus Fangji decoction in the treatment of delayed lymphedema caused by postoperative local radiotherapy for laryngeal carcinoma. Methods 60 patients with laryngeal carcinoma treated by radiotherapy after operation were divided into traditional Chinese medicine treatment group and control group with 30 cases in each group. Each group consisted of 20 cases of partial laryngectomy and 10 cases of total laryngectomy. In the control group, 13 cases underwent neck lymph node dissection, only routine intensity modulated radiotherapy was given after operation, and 16 cases were treated with traditional Chinese medicine treatment group. After operation, the patients were treated with intensity modulated radiotherapy (IMRT) at the same time as Huangqi Fangji decoction, 1 dose per day, divided into 2 oral doses, the course of treatment of traditional Chinese medicine was 10 weeks, and one month after the end of radiotherapy. Delayed lymphedema of larynx and neck were evaluated by modified Miller and LENT-SOMA scoring system. Visual scale was used to evaluate the quality of life of the patients. Results compared with the control group, the response grade of larynx and neck delayed lymphedema in the Chinese medicine treatment group was significantly lower than that in the control group (P0.01). Conclusion the addition and subtraction of Huangqi Fangji decoction can effectively prevent and reduce the delayed lymphedema induced by radiotherapy.
【作者单位】： 江苏省苏州市苏州大学附属第一医院耳鼻咽喉科;江苏省苏州市苏州大学附属第一医院中医科;
【分类号】：R739.65
【正文快照】： 对于喉癌术后放疗,喉及颈部淋巴水肿是最常见的急性或迟发放疗反应。临床医生常用肾上腺皮质激素、利尿剂、β-七叶皂苷钠等处理水肿,这些药物都只能起短暂的作用,对于缓解由于组织纤维化导致的水肿疗效欠佳[1]。很多学者针对减少放疗的毒副作用做了大量的研究,包括采用各种放，

本文编号：1454176