鼻咽癌组织p-eIF4E和p-4EBP1高表达与预后不良正相关

发布时间：2018-01-28 01:37

本文关键词： 磷酸化的真核细胞翻译起始因子E(p-eIFE) 磷酸化的eIFE结合蛋白(p-EBP) 鼻咽癌(NPC)　出处：《细胞与分子免疫学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨磷酸化的真核细胞翻译起始因子4E(p-eIF4E)和磷酸化的eIF4E结合蛋白1(p-4EBP1)与鼻咽癌(NPC)临床病理特征和预后的相关性。方法免疫组织化学染色法检测314例NPC组织中p-eIF4E和p-4EBP1蛋白表达,利用SPSS16.0软件分析p-eIF4E和p-4EBP1蛋白表达与NPC临床病理特征及预后的相关性。结果 NPC组织中存在p-eIF4E和p-4EBP1蛋白异常高表达,阳性表达率分别为74.2%(233/314)、72.9%(229/314);p-eIF4E和p-4EBP1蛋白表达在淋巴结转移NPC组织中阳性表达率显著高于无淋巴结转移NPC组织,但与性别、年龄、临床分期和组织类型无关;NPC组织中p-eIF4E与p-4EBP1蛋白表达呈正相关,且p-eIF4E和p-4EBP1蛋白阳性的NPC患者生存时间明显短于p-eIF4E和p-4EBP1阴性患者,是NPC判断预后的独立因素。结论 p-eIF4E和p-4EBP1蛋白过表达可能与NPC的发生、发展及不良预后密切相关,p-eIF4E和p-4EBP1有望成为NPC临床诊治和判断预后的分子标志物。
[Abstract]:Objective to investigate the relationship between phosphorylated eukaryotic cell translation initiation factor (4EP-eIF4E), phosphorylated eIF4E binding protein 1p4EBP1) and nasopharyngeal carcinoma (NPC). Methods the expression of p-eIF4E and p-4EBP1 protein was detected by immunohistochemical staining in 314 cases of NPC. The correlation between the expression of p-eIF4E and p-4EBP1 protein and the clinicopathological features and prognosis of NPC was analyzed by SPSS16.0 software. There were abnormal overexpression of p-eIF4E and p-4EBP1 proteins in NPC. The positive expression rates were 74.2% and 233 / 314g / 72.9%, respectively. The positive expression rate of p-eIF4E and p-4EBP1 protein in NPC with lymph node metastasis was significantly higher than that in NPC without lymph node metastasis, but it was associated with sex and age. There was no correlation between clinical stage and histological type. There was a positive correlation between p-eIF4E and p-4EBP1 protein expression in NPC. The survival time of patients with p-eIF4E and p-4EBP1 protein positive NPC was significantly shorter than that of p-eIF4E and p-4EBP1 negative patients. Conclusion the overexpression of p-eIF4E and p-4EBP1 protein may be closely related to the occurrence, development and poor prognosis of NPC. P-eIF4E and p-4EBP1 are expected to be molecular markers for clinical diagnosis, treatment and prognosis of NPC.
【作者单位】：山西省长治医学院生化教研室;湖南省中南大学湘雅二医院病理科;山西省长治医学院附属和平医院妇科;
【基金】：长治医学院科技创新项目(CX201502)
【分类号】：R739.63
【正文快照】： 鼻咽癌(nasopharyngeal carcinoma,NPC)是EB病毒感染引起的独特的头颈部恶性肿瘤,高发于东南亚地区。由于发病隐匿,所以临床晚期NPC患者居多。目前放化疗是NPC的首选治疗方案,但复发和转移率较高,预后较差[1-3]。因此,寻找NPC早期诊治和判断预后的分子标志具有重要意义。真核

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