成人OSAHS患者短程无创正压通气治疗前后血清髓过氧化物酶、胰淀素的水平测定及意义

发布时间：2018-01-29 02:13

  本文关键词： 睡眠呼吸暂停低通气综合征 阻塞性 髓过氧化物酶 胰淀素 胰岛素抵抗　出处：《临床耳鼻咽喉头颈外科杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的:探讨成人OSAHS患者短程无创正压通气(CPAP)治疗前后血清髓过氧化物酶(MPO)、胰淀素的水平测定及意义。方法:87例OSAHS患者根据AHI分为重度组(30例)、中度组(30例)、轻度组(27例);以门诊健康者27例为对照组。采用ELISA法测定受试者血清MPO和胰淀素。30例重度OSAHS患者行CPAP治疗3个月和6个月复测MPO、胰淀素,分析MPO、胰淀素与PSG指标的关系。结果:(1)随着OSAHS病情程度增加,血MPO、胰淀素水平均逐渐上升(F=22.486,19.755;P0.01);其中轻度组与对照组MPO、胰淀素浓度差异无统计学意义(P0.05),余各间相互比较均有明显差别(P0.01)。(2)OSAHS患者血清MPO、胰淀素水平和BMI、年龄没有关联(P0.05),与LSaO_2呈负相关,和AHI呈正相关(P0.01);血MPO与胰淀素水平呈正相关(r=0.466,P0.01)。(3)30例重度患者经CPAP治疗3个月LSaO_2较前上升,AHI及外周血MPO、胰淀素水平较前降低(P0.01);治疗6个月MPO、胰淀素水平较治疗3个月降低(P0.05),但与对照组比较仍有升高(P0.05)。结论:联合测定成人OSAHS患者血清胰淀素、MPO浓度对病情、疗效的判断及并发糖尿病及胰岛素抵抗危险性预测有一定参考价值。CPAP治疗可明显降低OSAHS患者缺氧程度和胰岛功能损害,其疗效和疗程相关。
[Abstract]:Objective: to investigate the serum myeloperoxidase (MPO) in adult patients with OSAHS before and after treatment. Methods Eighty-seven patients with OSAHS were divided into severe group (n = 30), moderate group (n = 30) and mild group (n = 27) according to AHI. The serum MPO and amylin in 30 patients with severe OSAHS were measured by ELISA method. MPO was measured in 3 and 6 months after CPAP treatment. Amylin, analysis of the relationship between OSAHS, amylin and PSG index. Results: with the increase of the degree of OSAHS, the levels of plasma MPO and amylin increased gradually. 19.755; P0.01; There was no significant difference in MPO and amylin concentrations between mild group and control group (P 0.05). There were significant differences in serum MPO, amylin levels and BMI. there was no correlation between the age of MPO and amylin in patients with OSAHS (P0.05). There was a negative correlation with LSaO_2 and a positive correlation with AHI (P 0.01). There was a positive correlation between serum MPO and amylin levels in 30 cases of severe patients treated with CPAP for 3 months. The levels of AHI, MPO and amylin in peripheral blood were significantly lower than those in control group (P 0.01). After 6 months of treatment with MPO, the level of amylin was lower than that of 3 months (P 0.05). Conclusion: combined determination of serum amylin and amylin in adult patients with OSAHS is effective in the treatment of the disease. The evaluation of curative effect and risk prediction of diabetes mellitus and insulin resistance have certain reference value. CPAP treatment can significantly reduce the degree of hypoxia and islet function damage in patients with OSAHS, and its curative effect is related to the course of treatment.
【作者单位】： 中山大学附属第八医院(深圳福田)耳鼻咽喉头颈外科;深圳市第七人民医院检验科;
【分类号】：R766
【正文快照】： OSAHS患者可合并糖代谢紊乱,早期常表现为胰岛素抵抗[1],但具体机制尚未明了。研究认为[2],OSAHS患者间断缺氧致机体氧化应激增加的病理过程在合并全身多器官损害的机制中作用重大。胰岛组织抗氧化酶含量很低,其内胰岛细胞对氧化应激反应十分敏感[3]。髓过氧化物酶(MPO)是一种，

本文编号：1472217