高压氧对兔鼻腔手术后黏膜炎症反应的影响

发布时间：2018-01-29 18:59

本文关键词： 外科手术鼻窦炎高压氧鼻黏膜炎症　出处：《临床耳鼻咽喉头颈外科杂志》2017年16期 　论文类型：期刊论文

【摘要】：目的:观察高压氧治疗后兔鼻腔手术区炎症反应的情况,探讨高压氧治疗在鼻腔手术后恢复过程中降低炎性反应、促进黏膜愈合的临床可行性。方法:合格日本大耳白兔16只创建双侧鼻腔手术模型,随机分为高压氧组和非高压氧组各8只,另设5只正常对照组。非高压氧组术后处于常规常压环境,高压氧组术后第5天开始高压氧治疗。于术后第6周处死全部动物,取双侧下鼻甲手术区黏膜观察大体形态及病理学改变。正常对照组取相同部位黏膜观察。结果:大体标本:高压氧组术区积脓2侧,非高压氧组8侧,高压氧组较非高压氧组明显减少,差异有统计学意义(P0.05);病理改变:高压氧组炎细胞浸润轻度12侧,中度4侧;非高压氧组轻度1侧,中度13侧,重度2侧,高压氧组较非高压氧组明显减轻,差异有统计学意义(P0.01)。结论:在本实验条件下,高压氧治疗可明显减轻兔鼻腔手术后黏膜的炎症反应,减少术后鼻腔脓性分泌物的积蓄。
[Abstract]:Objective: to observe the inflammatory response in rabbit nasal cavity after hyperbaric oxygen therapy and to explore the reduction of inflammatory response during the recovery of hyperbaric oxygen therapy. Methods: sixteen Japanese rabbits were randomly divided into hyperbaric oxygen group and non-hyperbaric oxygen group. In addition, five normal control groups were set up. The non-hyperbaric oxygen group was in the normal pressure environment after operation, and the hyperbaric oxygen group began to be treated with hyperbaric oxygen on the 5th day after operation. All the animals were killed at the 6th week after operation. Gross morphology and pathological changes of mucosa in bilateral inferior turbinate were observed. The normal control group was observed at the same site. Results: the gross specimen: hyperbaric oxygen group (2 sides) and non-hyperbaric oxygen group (8 sides). Hyperbaric oxygen group was significantly lower than that of non-hyperbaric oxygen group, the difference was statistically significant (P 0.05). Pathological changes: in hyperbaric oxygen group, inflammatory cell infiltration was mild in 12 sides and moderate in 4 sides; Non-hyperbaric oxygen group mild 1 side, moderate 13 sides, severe 2 sides, hyperbaric oxygen group than non-hyperbaric oxygen group significantly reduced, the difference was statistically significant (P 0.01). Conclusion: under this experimental conditions. Hyperbaric oxygen therapy can obviously reduce the inflammatory reaction of rabbit nasal mucosa and reduce the accumulation of purulent secretion after nasal cavity operation.
【作者单位】：凉山州第一人民医院耳鼻咽喉科;
【基金】：凉山州学术和技术带头人培养资金资助项目
【分类号】：R765.9
【正文快照】： 内镜鼻窦手术(endoscopic sinus surgery,ESS)术后黏膜形态和功能的恢复对手术整体预后有着举足轻重的影响,术腔护理和术后综合性治疗越来越受到临床重视,黏膜的慢性炎症反应是术后迁延不愈的重要原因,局部和全身性多种炎性和感染因素参与的慢性进程是疾病复杂性的基础[1]。在

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