青年和中老年视神经炎患者的临床特点比较

发布时间：2018-01-30 02:45

本文关键词： 视神经炎 MRI 多发性硬化激素治疗　出处：《广西医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：比较不同年龄阶段视神经炎的临床特点是否有差异及糖皮质激素治疗安全性。方法：收集2003年1月---2014年3月在广西医科大学第一附属医院眼科中心就诊及确诊为视神经炎患者的临床资料。根据联合国世界卫生组织与中国标准按年龄分段分为两组：青年组(18岁～44岁)和中老年组(44岁),回顾分析及了解两组的一般临床特点。结果：本研究项目最后纳入有184例(268只眼)的视神经炎患者。与青年组比较,中老年组视盘水肿比率低(24.8%vs 7.8%,P=0.010),脑室周围脱髓鞘样斑块比率高(7.5% vs 21.6%,P=0.007)。青年组及中老年组研究其他结果显示：性别(P=0.379),眼别(P=0.796),眼疼痛(P=0.853),诊断为多发性硬化(P=0.799),就诊时间(P=0.773),住院时间(P=0.533),激素药物分组(P=0.134)两组无显著性差异。中老年组的激素副作用发生比例较青年组高(P0.001)结论：这项研究表明中老年组与青年组视神经炎临床特征基本相似,中老年患者用激素冲击是安全的,但是需要注意监测激素副作用。
[Abstract]:Objective: to compare the clinical characteristics and the safety of glucocorticoid in the treatment of optic neuritis at different ages. The clinical data of patients with optic neuritis were collected from January 2003 to March 2014 in the Eye Center of the first affiliated Hospital of Guangxi Medical University. According to the United Nations World Health Organization and Chinese standards. Divided into two groups according to age:. Youth Section (. 18 years old to 44 years old) and middle and old age group to 44 years old). Results: 184 cases (268 eyes) with optic neuritis were included in this study. In the middle and old age group, the optic disc edema rate was 24. 8% vs 7. 8%, and the ratio of periventricular demyelinating plaques was 7. 5% vs 21.6%. Other results of the study in the young group and the middle and old age group were as follows: sex was 0.379, eye pain was 0.796, eye pain was P0.853). The diagnosis was multiple sclerosis (P < 0. 799), the time of seeing a doctor was 0. 773, and the time of hospitalization was 0. 533). There was no significant difference between the two groups. The incidence of hormone side effects in the middle and old age group was higher than that in the young group (P 0.001). Conclusion: this study shows that the clinical features of optic neuritis in the middle and old age group are basically similar. It is safe to use hormone shock in middle-aged patients, but it is necessary to monitor hormone side effects.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R774.61

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