缺铁性贫血和健康儿童视网膜神经纤维层厚度的对比分析

发布时间：2018-01-30 09:59

本文关键词： 缺铁性贫血视网膜神经纤维层血红蛋白　出处：《眼科新进展》2017年01期 　论文类型：期刊论文

【摘要】：目的对比分析缺铁性贫血(iron deficiency anemia,IDA)儿童和健康儿童的视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度。方法选取IDA儿童58例116眼和健康儿童46例92眼,分别纳入IDA组和对照组。对所有儿童进行眼压、等效球镜度和血红蛋白浓度测定,并于同日进行光学相干断层扫描仪检测,以获得上方、下方、鼻侧、颞侧和平均RNFL厚度。IDA组儿童接受铁剂治疗后检测RNFL厚度和血红蛋白浓度的变化。使用SPSS 19.0对数据进行统计学分析。结果与健康儿童相比,IDA儿童的RNFL厚度较薄。对于合并IDA的青光眼或视神经病变儿童,应综合进行贫血的内科治疗。IDA组儿童血红蛋白浓度显著低于对照组(t=-21.99,P=0.00),分别为(69.59±5.78)g·L~(-1)和(145.46±6.20)g·L~(-1)。IDA组儿童上方、下方和平均RNFL厚度均低于对照组(均为P0.05),而鼻侧和颞侧RNFL厚度与对照组差异均无统计学意义(均为P0.05)。对IDA儿童的平均RNFL厚度和同期血红蛋白浓度行Spearman相关分析,结果显示平均RNFL厚度与血红蛋白浓度呈正相关(r=0.725,P=0.03)。IDA组儿童接受规范的铁剂治疗后,血红蛋白浓度由(69.59±5.78)g·L~(-1)上升到(132.47±6.24)g·L~(-1)。此时所有儿童均接受OCT复查RNFL厚度。结果显示上方、下方、鼻侧、颞侧和平均RNFL厚度分别为(180.11±50.58)μm、(168.79±47.14)μm、(188.57±39.86)μm、(185.34±42.67)μm和(180.48±41.98)μm,铁剂治疗后上方RNFL厚度较治疗前有所增厚(t=-21.25,P=0.04)。结论与健康儿童相比,IDA儿童的RNFL厚度较薄。对于合并IDA的青光眼或视神经病变儿童,应综合进行贫血的内科治疗。
[Abstract]:Objective to compare iron deficiency anemia in iron deficiency anemia. Ida) retinal nerve fiber layer in children and healthy children. Methods 58 IDA children (116 eyes) and 46 healthy children (92 eyes) were included in IDA group and control group. Intraocular pressure (IOP) was performed in all children. The equivalent spheroscopy and hemoglobin concentration were measured, and optical coherence tomography was performed on the same day to obtain the upper, lower and nasal sides. Temporal and mean RNFL thickness. The changes of RNFL thickness and hemoglobin concentration were measured after iron treatment. SPSS was used. 19.0 the data were analyzed statistically. The results were compared with those of healthy children. The thickness of RNFL was thinner in children with IDA. In children with glaucoma or optic neuropathy complicated with IDA. The hemoglobin concentration of children in IDA group was significantly lower than that in control group (P 0.00). 69.59 卤5.78 g 路L ~ (-1) and 145.46 卤6.20 g 路L ~ (-1) 路L ~ (-1), respectively. The thickness of lower and average RNFL was lower than that of control group (P0.05). There was no significant difference in the thickness of RNFL between nasal side and temporal side (P 0.05). The mean RNFL thickness and hemoglobin concentration in children with IDA were analyzed by Spearman correlation. The results showed that there was a positive correlation between the mean thickness of RNFL and the concentration of hemoglobin. The concentration of hemoglobin increased from 69.59 卤5.78 g 路L ~ (-1) to 132.47 卤6.24 g 路L ~ (-1). All children were examined by OCT for RNFL thickness. The inferior, nasal, temporal and average RNFL thickness were 180.11 卤50.58 渭 m and 168.79 卤47.14 渭 m, respectively. 188.57 卤39.86) 渭 m and 185.34 卤42.67 渭 m and 180.48 卤41.98 渭 m respectively. The thickness of upper RNFL was thicker than that before treatment. Conclusion compared with healthy children, the thickness of RNFL is 0.04%. The thickness of RNFL in children with IDA is thinner. For children with glaucoma or optic neuropathy complicated with IDA, comprehensive medical treatment of anemia should be given.
【作者单位】：武汉市第一医院;
【基金】：武汉市卫计委基金资助(编号:WX14B05)~~
【分类号】：R725.5;R771.3
【正文快照】： 由铁摄入不足引起的缺铁性贫血(iron deficiency anemia,IDA)是世界范围内最常见的贫血类型之一。据统计,发展中国家儿童群体IDA发病率约为20%[1]。在我国,IDA多发于婴幼儿,其中7~12个月婴儿发病率约20.5%,7个月~7岁儿童发病率约7.8%[2]。以往研究表明,铁作为一种必需的微量元

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