小儿急性鼻窦炎呼吸道病原体筛查与临床特征分析

发布时间：2018-01-30 22:46

本文关键词： 小儿急性鼻窦炎呼吸道病原体筛查　出处：《世界复合医学》2016年03期 　论文类型：期刊论文

【摘要】：目的急性上呼吸道感染(URI)是儿科门诊最常见的疾病之一,其病毒学病因发挥着重要的作用。由于病毒对鼻腔、鼻窦上皮细胞及纤毛的损害,URI的感染多数会进一步导致小儿的鼻窦炎感染。因此,通过病原体筛选和临床特征分析,来比较急性鼻窦炎(ARS)组与对照组的病毒发生率。方法对该组564例儿科患者进行鼻粘膜拭子采样,其中259例为ARS患儿(I组),219例为急性URI患儿(II组),86名为对照组(III组)。应用多重PCR技术对每组的呼吸道病毒及病原体进行比较。结果感染了呼吸道病毒的患儿进一步发展为鼻窦炎(RS)的风险将增加3.104倍(RR=3.104,95%CI=2.134~4.517)。I组中的鼻病毒(RV)与腺病毒(ADV)含量均高于II组(P0.05),其余的病原体在两组间的差异无统计学意义(P0.05)。Ia组(单纯ARS组)中RV的感染率明显高于其他组(P0.01);与其他组比较,ADV的感染率在Ib组(急性URI伴ARS)患儿中更常见(P0.05)。鼻腔分泌物的涂片分析结果显示,49.6%的I组样品中可见免疫细胞的渗出,此结果几乎与该组的病原体检出率(47.4%)相等。结论小儿急性URI发展为ARS的的患者中,病毒RV与ADV担当了比较重要的作用,特别是RV,这部分患儿的鼻腔分泌物中可见中性粒细胞和淋巴细胞的渗出。应该通过不同的采样医院,在连续季节收集更多的ARS样本量,以便更好地推广该研究。
[Abstract]:Objective Acute upper respiratory tract infection (URI) is one of the most common diseases in pediatric outpatient clinic. Virological etiology plays an important role. Most infections of URI can lead to sinusitis in children. Therefore, pathogen screening and clinical analysis are used. Methods A total of 564 pediatric patients with acute sinusitis were sampled from nasal mucosal swabs, of which 259 were children with ARS. There were 219 children with acute URI in group II. 86 patients in control group III were compared with each group of respiratory viruses and pathogens by using multiple PCR techniques. Results the children infected with respiratory viruses developed further into sinusitis. The risk will increase by 3.104 times RRN 3.104. The contents of rhinovirus RV (RV) and adenovirus (ADV) in group I were higher than those in group II (P 0.05). The infection rate of RV in group Ia (simple ARS group) was significantly higher than that in other groups (P0.01). Compared with other groups, the infection rate of ADV was more common in Ib group (acute URI with ARS) than in other groups. The results of smear analysis of nasal secretion showed that the infection rate was more common in Ib group (acute URI with ARSs) than in other groups. The immunocyte exudation was seen in group I of 49.6%, which was almost equal to the detection rate of pathogens in this group. Conclusion in children with acute URI, the rate of development of ARS is 47.4%. Virus RV and ADV play a more important role, especially RV, the nasal secretion of this part of children can see neutrophil and lymphocyte exudation. In order to popularize the study, more ARS samples are collected in successive seasons.
【作者单位】：广州医科大学附属第一医院耳鼻喉科;广东省妇幼保健院检验科;广州医科大学附属第一医院儿科;广州医科大学附属第一医院检验科;广州中医药大学第二附属医院检验科;
【基金】：广东省科技计划项目(2011B061300038)
【分类号】：R765.41
【正文快照】： Acute rhinosinusitis(ARS)is a common problem in children with acute upper respiratory tract infections(AURIs),while AURIs is the largest number of disease in pediatric outpatients.Recent evidence shows that most URIs are caused by viruses,but the viral s

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