香菊胶囊联合氮卓斯汀治疗过敏性鼻炎的临床研究

发布时间：2018-02-01 05:30

本文关键词： 香菊胶囊盐酸氮卓斯汀鼻喷雾剂过敏性鼻炎症状评分血清学指标　出处：《现代药物与临床》2016年06期 　论文类型：期刊论文

【摘要】：目的探究香菊胶囊联合氮卓斯汀治疗过敏性鼻炎的临床疗效。方法选取2014年8月—2015年8月首都医科大学附属北京潞河医院耳鼻喉科收治的过敏性鼻炎患者216例,根据不同的治疗方案分对照组和治疗组,每组各108例。对照组给予盐酸氮卓斯汀鼻喷雾剂,每侧鼻孔1喷/次,2次/d。治疗组在对照组基础上口服香菊胶囊,3粒/次,3次/d。两组均连续治疗1个月。观察两组的临床疗效,同时比较两组患者的症状评分和血清学指标的情况。结果治疗后,对照组和治疗组的总有效率分别为85.19%、93.52%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者打喷嚏、流涕、鼻塞、鼻痒及总分均显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗组这些观察指标改善程度明显优于对照组,两组比较差异有统计学意义(P0.05)。治疗后,两组患者IL-12、IFN-γ水平显著升高,而IL-4、IL-10、Ig E水平显著降低,同组治疗前后差异有统计学意义(P0.05);且治疗组这些观察指标改善程度明显优于对照组,两组比较差异有统计学意义(P0.05)。结论香菊胶囊联合氮卓斯汀治疗过敏性鼻炎具有较好的临床疗效,可缓解临床症状,提高机体的免疫能力,具有一定临床推广应用价值。
[Abstract]:Objective to investigate the clinical effect of Xiangju capsule combined with azobrostine in the treatment of allergic rhinitis. Methods from August 2014 to August 2015, allergic rhinitis in the department of otolaryngology, Beijing Luhe Hospital, Capital Medical University was selected. 216 cases of rhinitis. According to different treatment schemes, each group was divided into control group and treatment group with 108 cases in each group. The control group was given azostidine hydrochloride nasal spray once a time in each side of nostril. 2 / d. The treatment group took 3 capsules of Xiangju capsule / 3 times per day on the basis of the control group. The two groups were treated continuously for 1 month. The clinical efficacy of the two groups was observed. Results after treatment, the total effective rates of the control group and the treatment group were 85.19% and 93.52%, respectively. After treatment, the two groups of patients sneeze, runny, nasal congestion, nasal itching and total score significantly decreased. The difference before and after treatment in the same group was statistically significant (P 0.05). The improvement of these indexes in the treatment group was significantly better than that in the control group, and the difference between the two groups was statistically significant (P 0.05). After treatment, the level of IL-12 and IFN- 纬 increased significantly in the two groups. The level of IL-10 Ig E in the same group was significantly lower than that in the control group (P 0.05). The improvement of these indexes in the treatment group was significantly better than that in the control group. Conclusion Xiangju capsule combined with azobrostine has a good clinical effect on allergic rhinitis, can alleviate clinical symptoms and improve the immune ability of the body. It has certain clinical popularization and application value.
【作者单位】：北京中医药大学东直门医院东区耳鼻咽喉科;首都医科大学附属北京潞河医院耳鼻咽喉科;
【分类号】：R765.21
【正文快照】： 过敏性鼻炎是特应性个体接触致敏原后由免疫球蛋白E(Ig E)介导的介质(主要是组胺)释放,并有多种免疫活性细胞和细胞因子等参与的鼻黏膜慢性炎症反应性疾病,临床上以鼻痒、打喷嚏、鼻分泌亢进、鼻黏膜肿胀等主要表现,严重影响患者的工作和学习[1]。在中国的一项调查问卷中显示,

【相似文献】