非增生型糖尿病视网膜病变患者黄斑水肿与中心凹下脉络膜厚度的关系

发布时间：2018-02-04 11:57

本文关键词： 脉络膜光学相干断层扫描非增生型糖尿病视网膜病变黄斑水肿　出处：《眼科新进展》2017年03期 　论文类型：期刊论文

【摘要】：目的观察非增生型糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)伴临床有意义的黄斑水肿(clinically significant macular edema,CSME)时黄斑中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT)的情况,探讨糖尿病患者SFCT与糖尿病视网膜病变发生发展的关系。方法按2014年我国糖尿病视网膜病变临床诊疗指南分期标准将NPDR患者分为伴CSME(NPDR CSME+)组15例(21眼),不伴CSME(NPDR CSME-)组21例(36眼)。比较两组之间最佳矫正视力、黄斑中心凹视网膜厚度(central retinal thickness,CRT)及SFCT是否存在差异性。采用SPSS 18.0软件进行统计学分析处理。结果NPDR CSME+组与NP-DR CSME-组间性别、眼别、年龄、眼轴长度、眼压相比差异均无统计学意义(均为P0.05),两组间最佳矫正视力相比差异有统计学意义(P=0.001)。NPDR CSME+组SFCT为(328.24±101.92)μm,NPDR CSME-组为(235.31±66.98)μm,两组间差异具有统计学意义(t=4.156,P=0.000)。NPDR患眼CRT与SFCT呈正相关关系(r=0.473,P=0.000)。结论NPDR伴有CSME时,SFCT显著增厚,并且SFCT的增厚与CSME的发生发展具有一定相关性。
[Abstract]:Objective to observe non-proliferative diabetic retinopathy of non-proliferative diabetic retinopathy. Significant macular edema with clinically significant macular edema. The thickness of subfoveal choroidal thicknessn (SFCTs) of central foveal foveal foveal chorion. To investigate the relationship between SFCT and the development of diabetic retinopathy in diabetic patients methods according to the criteria of clinical diagnosis and treatment of diabetic retinopathy in 2014, NPDR patients were divided into NPDR patients with CSME. (. NPDR CSME group (15 cases, 21 eyes). The best corrected visual acuity (BCVA) was compared in 21 cases (36 eyes) without CSME(NPDR CSME-group. Central retinal thickness. The differences between CRT and SFCT were analyzed by SPSS 18.0 software. Results the sex between NPDR CSME group and NP-DR CSME-group was analyzed. There was no significant difference in eye type, age, axial length and intraocular pressure (all P 0.05). The difference of best corrected visual acuity (BCVA) between the two groups was statistically significant. The SFCT of CSME group was 328.24 卤101.92 渭 m. The NPDR CSME-group was 235.31 卤66.98 渭 m, and the difference between the two groups was statistically significant. There was a positive correlation between CRT and SFCT in the eyes with Pu 0.000.NPDR. Conclusion NPDR with CSME is significantly thicker. The thickening of SFCT is related to the occurrence and development of CSME.
【作者单位】：蚌埠市第二人民医院眼科;福州总医院厦门大学附属东方医院福建医科大学福总临床医学院;
【基金】：全军医药卫生科研重大项目(编号:15ZD041) 福建省科技厅重点项目(编号:2016Y0067)~~
【分类号】：R774.1;R587.2
【正文快照】： 视网膜有视网膜循环及脉络膜循环两个血管网,一般情况下视网膜循环为视网膜内五层供给营养,而脉络膜循环主要负责外五层包括视网膜色素上皮(retinal pigment epithelium,RPE)层和光感受器在内的营养物质输入以及代谢产物输出。故脉络膜毛细血管的病变会导致黄斑区视网膜组织的

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